Neuromodulated Spike-Timing-Dependent Plasticity, and Theory of Three-Factor Learning Rules.
Neuromodulated Spike-Timing-Dependent Plasticity, and Theory of Three-Factor Learning Rules.
复制标题
DOI：
10.3389/fncir.2015.00085
复制
发表时间：
2015
影响因子：
3.5
通讯作者：
Gerstner W
中科院分区：
文献类型：
--
作者：
Frémaux N;Gerstner W
经典的赫布学习强调突触前和突触后的联合活动，但忽略了神经调质的潜在作用。由于神经调质传递有关新奇或奖励的信息，神经调质对突触可塑性的影响不仅对经典条件反射中的动作学习有用，而且还可以决定“何时”创建新的记忆以响应感官刺激。在这篇综述中，我们专注于结合一个或几个阶段性神经调节信号的突触前和突触后活动的时间要求。虽然重点的文字是概念模型和数学理论，我们也讨论了一些实验证据的神经调制尖峰定时依赖可塑性。我们强调的重要性，突触机制在弥合感官刺激和神经调节信号之间的时间差距，并制定了一个框架的一类新Hebbian三因素的学习规则，依赖于突触前活动，突触后变量以及神经调质的影响。
Classical Hebbian learning puts the emphasis on joint pre- and postsynaptic activity, but neglects the potential role of neuromodulators. Since neuromodulators convey information about novelty or reward, the influence of neuromodulators on synaptic plasticity is useful not just for action learning in classical conditioning, but also to decide “when” to create new memories in response to a flow of sensory stimuli. In this review, we focus on timing requirements for pre- and postsynaptic activity in conjunction with one or several phasic neuromodulatory signals. While the emphasis of the text is on conceptual models and mathematical theories, we also discuss some experimental evidence for neuromodulation of Spike-Timing-Dependent Plasticity. We highlight the importance of synaptic mechanisms in bridging the temporal gap between sensory stimulation and neuromodulatory signals, and develop a framework for a class of neo-Hebbian three-factor learning rules that depend on presynaptic activity, postsynaptic variables as well as the influence of neuromodulators.