Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer.
Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer.
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DOI：
10.1016/j.ccr.2013.06.003
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发表时间：
2013-08-12
期刊：
影响因子：
50.3
通讯作者：
Espinosa L
中科院分区：
文献类型：
--
作者：
Mulero MC;Ferres-Marco D;Islam A;Margalef P;Pecoraro M;Toll A;Drechsel N;Charneco C;Davis S;Bellora N;Gallardo F;López-Arribillaga E;Asensio-Juan E;Rodilla V;González J;Iglesias M;Shih V;Mar Albà M;Di Croce L;Hoffmann A;Miyamoto S;Villà-Freixa J;López-Bigas N;Keyes WM;Domínguez M;Bigas A;Espinosa L
IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of HOX and IRX genes. Chromatin-bound IκBα modulates Polycomb recruitment and imparts their competence to be activated by TNFα. Mutations in the Drosophila IκBα gene cactus enhance the homeotic phenotype of Polycomb mutants, which is not counteracted by mutations in dorsal/NF-κB. Oncogenic transformation of keratinocytes results in cytoplasmic IκBα translocation associated with a massive activation of Hox. Accumulation of cytoplasmic IκBα was found in squamous cell carcinoma (SCC) associated with IKK activation and HOX upregulation.
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DOI：
10.1084/jem.188.6.1055
发表时间：
1998-09-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cheng JD;Ryseck RP;Attar RM;Dambach D;Bravo R
通讯作者：
Bravo R
影响因子：
64.5
作者：
GEISLER, R;BERGMANN, A;NUSSLEINVOLHARD, C
通讯作者：
NUSSLEINVOLHARD, C
影响因子：
10.5
作者：
Ezhkova, Elena;Lien, Wen-Hui;Fuchs, Elaine
通讯作者：
Fuchs, Elaine
影响因子：
56.9
作者：
Cao, R;Wang, LJ;Zhang, Y
通讯作者：
Zhang, Y
影响因子：
64.5
作者：
Ezhkova E;Pasolli HA;Parker JS;Stokes N;Su IH;Hannon G;Tarakhovsky A;Fuchs E
通讯作者：
Fuchs E