Diabetes of 5 years duration does not lead to photoreceptor degeneration in the canine non-tapetal inferior-nasal retina.
Diabetes of 5 years duration does not lead to photoreceptor degeneration in the canine non-tapetal inferior-nasal retina.
复制标题
持续 5 年的糖尿病不会导致犬非绒毡层下鼻视网膜感光细胞变性。
DOI：
10.1016/j.exer.2017.07.009
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发表时间：
2017
影响因子：
3.4
通讯作者：
Kern,TimothyS
中科院分区：
文献类型：
--
作者：
Tonade,Deoye;Kern,TimothyS
糖尿病视网膜病变（diabetic retinopathy，DR）以视网膜血管损伤、视力损害和失明为特征，但视网膜神经元参与DR特征的研究正日益受到关注。研究者报道了关于糖尿病对视网膜中神经元细胞类型存活的影响的相互矛盾的结果。人们普遍认为，长期存在的糖尿病导致糖尿病视网膜神经节细胞数量减少，但糖尿病对视网膜感光细胞的影响尚不清楚。一些研究者已经提出证据表明，在糖尿病诱发后仅数月内，糖尿病啮齿动物中存在一些或实质性的感光细胞变性（Énzsöly等人，2014年; Tang等人，2011; Bogdanov等人，2014），而其他人已经发现很少或没有证据表明糖尿病小鼠或患者在甚至更长的疾病持续时间后光感受器的普遍损失（Liu et al.，2016; Hombrebueno等人，2014年; Tan等人，2015; Gerhardinger等人，1998）。我们先前对糖尿病狗进行了5年的研究以调查血糖控制的作用（豪厄尔等人，二〇一三年; Engerman和克恩，1987）或实验性疗法（克恩和Engerman，2001; Engerman和克恩，1993）对糖尿病性视网膜病变的发展的影响，并且显示狗中的PC或MC糖尿病导致DR的特征性血管病变，当以足以实现良好血糖控制的量施用胰岛素时，其减轻（Engerman和克恩，1987; Engerman等人，1977年）。同样，视神经中的轴突过程（其被解释为指示视网膜神经节细胞的减少）也被发现。
Diabetic retinopathy (DR) is characterized by retinal vascular damage, visual impairment and blindness, but the involvement of retinal neurons in characteristics of DR is now gaining attention. Investigators have reported conflicting results with respect to the effects of diabetes on survival of neuronal cell-types in the retina. There is general agreement that long-standing diabetes leads to a reduction in the number of retinal ganglion cells in diabetes, but the effect of diabetes on retinal photoreceptor cells is less clear. Some investigators have presented evidence that there is some or substantial photoreceptor cell degeneration in diabetic rodents within only months after the induction of diabetes (Énzsöly et al., 2014; Tang et al., 2011; Bogdanov et al., 2014), whereas others have found little or no evidence of generalized loss of photoreceptors in diabetic mice or patients after even longer durations of disease (Liu et al., 2016; Hombrebueno et al., 2014; Tan et al., 2015; Gerhardinger et al., 1998).We previously conducted 5 year studies of diabetic dogs to investigate the roles of glycemic control (Howell et al., 2013; Engerman and Kern, 1987) or experimental therapies (Kern and Engerman, 2001; Engerman and Kern, 1993) on the development of diabetic retinopathy, and showed that PC or MC diabetes in dogs resulted in characteristic vascular lesions of DR, which were alleviated when insulin was administered in amounts adequate to achieve good glycemic control (Engerman and Kern, 1987; Engerman et al., 1977). Likewise, axonal processes in the optic nerve (which was interpreted as indicating a reduction in the retinal