Young age at diagnosis is associated with worse prognosis in the Luminal A breast cancer subtype: a retrospective institutional cohort study.
Young age at diagnosis is associated with worse prognosis in the Luminal A breast cancer subtype: a retrospective institutional cohort study.
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DOI：
10.1007/s10549-018-4950-4
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发表时间：
2018-12
影响因子：
3.8
通讯作者：
Umbricht CB
中科院分区：
文献类型：
--
作者：
Liu Z;Sahli Z;Wang Y;Wolff AC;Cope LM;Umbricht CB
虽然年龄是公认的独立预后危险因素，但其在乳腺癌分子亚型(BCA)中的相对重要性还没有很好的文献记载。本研究的目的是评估不同免疫组织化学亚型中年龄在诊断BCA时的预后作用。我们对在约翰霍普金斯医院接受手术的侵袭性BCA患者进行了一项回顾性研究，排除了表现为IV期乳腺癌的患者。患者被分成三个年龄组：≤40岁、41-60岁和>；60岁，并使用COX回归进行多变量分析。我们还在公共TCGA数据集中确定了BCA亚型中不同年龄组之间的差异表达基因(DEG)。最后，我们利用加权基因共表达网络分析确定了DEGS中的关键驱动基因。与41~60岁组相比，≤40岁组患者的5年无瘤生存率(DFS)和无远处转移生存率(DMFS)显著低于41~60岁组，而其他分子亚型与年龄无显著相关性。在腔内A型BCA患者中，年龄是比肿瘤分级或增殖指数更强的预后预测因子，但不是其他亚型。将BCATCGA基因表达数据分为两组(≤40岁，>；40岁)。我们在LuminalABCA亚群中鉴定出374个deGs，它们富含七条途径和两个共表达基因模块。在非管腔A亚型中未发现特定年龄组的Deg。确诊时的年龄可能是影响A型BCA预后的重要因素。
Although age is a recognized independent prognostic risk factor, its relative importance among molecular subtypes of Breast cancer (BCA) is not well documented. The aim of this study was to evaluate the prognostic role of age at diagnosis among different immunohistochemical subtypes of BCA. We conducted a retrospective study of women with invasive BCA undergoing surgery at the Johns Hopkins Hospital, excluding patients presenting with stage IV breast cancer. Patients were stratified into three age groups: ≤ 40, 41–60, and > 60 years, and multivariable analysis was performed using Cox regression. We also identified differentially expressed genes (DEG) between age groups among BCA subtypes in the public TCGA dataset. Finally, we identified key driver genes within the DEGs using a weighted gene co-expression network analysis. Luminal A breast cancer patients had significantly lower 5 year disease-free survival (DFS) and distant metastasisfree survival (DMFS) in the ≤ 40 year age group compared to the 41–60 year age group, while the other molecular subtypes showed no significant association of DFS or DMFS with age. Age was a stronger outcome predictor than tumor grade or proliferative index in Luminal A BCA patients, but not other subtypes. BCA TCGA gene expression data were divided into two groups (≤ 40 years, > 40 years). We identified 374 DEGs in the Luminal A BCA subset, which were enriched in seven pathways and two modules of co-expressed genes. No age group-specific DEGs were identified in non-Luminal A subtypes. Age at diagnosis may be an important prognostic factor in Luminal A BCA.
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WGCNA：用于加权相关网络分析的 R 包。
影响因子：
3
作者：
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通讯作者：
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影响因子：
3.8
作者：
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通讯作者：
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