The disappearing Barr body in breast and ovarian cancers
The disappearing Barr body in breast and ovarian cancers
复制标题
DOI：
10.1038/nrc2172
复制
发表时间：
2007-08-01
影响因子：
78.5
通讯作者：
Lawrence, Jeanne B.
中科院分区：
文献类型：
--
作者：
Pageau, Gayle J.;Hall, Lisa L.;Lawrence, Jeanne B.
最近，人们重新开始关注异染色质 X 染色体（巴尔体）缺失在某些乳腺癌和卵巢癌中是否普遍存在，并且对所涉及机制的新见解也出现了。有丝分裂分离错误通常可以解释失活 X 染色体 (Xi) 的丢失，但某些癌症中 Xi 异染色质的受损可能预示着核异染色质更广泛的缺陷。 BRCA1 和 Xi 之间有争议的联系可能反映了 BRCA1 和异染色质之间的一般关系，这可能将 BRCA1 与表观遗传和遗传不稳定性联系起来。我们认为异染色质不稳定性是一种常见但很大程度上未经探索的机制，导致广泛的基因组失调和一些癌症的进化。
Interest has recently reawakened in whether loss of the heterochromatic X chromosome (Barr body) is prevalent in certain breast and ovarian cancers, and new insights into the mechanisms involved have emerged. Mitotic segregation errors commonly explain the loss of the inactive X chromosome (Xi), but compromise of Xi heterochromatin in some cancers may signal broader deficits of nuclear heterochromatin. The debated link between BRCA1 and Xi might reflect a general relationship between BRCA1 and heterochromatin, which could connect BRCA1 to both epigenetic and genetic instability. We suggest that heterochromatic instability is a common but largely unexplored mechanism, leading to widespread genomic misregulation and the evolution of some cancers.