Quick self-healing and thermo-reversible liposome gel
Quick self-healing and thermo-reversible liposome gel
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DOI：
10.1016/j.colsurfb.2010.08.038
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发表时间：
2011-01-01
影响因子：
5.8
通讯作者：
Taguchi, Tetsushi
中科院分区：
文献类型：
--
作者：
Rao, Zhi;Inoue, Motoki;Taguchi, Tetsushi
通过流变学方法对脂质体和胆固醇封端聚乙二醇自组装的脂质体凝胶进行了系统研究，特别是在机械变形或温度变化时的恢复能力方面。发现脂质体凝胶具有与麦克斯韦模型相似的流变行为。脂质体凝胶的动态剪切模量取决于脂质体浓度和聚合物浓度。在低双体浓度范围（5-20 mM）动态剪切模量随脂质体浓度显着下降，这意味着由于脂质体的添加，凝胶网络内部的有效交联密度降低 脂质体凝胶网络即使在高度变形后仍具有快速自修复能力，并且通过体外注射实验证实了凝胶的可注射性 脂质体凝胶还表现出温度刺激响应行为和热可逆性 动态光散射研究证明，脂质体的粒径在添加聚合物之前和之后几乎保持不变 (C) 2010 Elsevier B V 版权所有
Self assembled liposome gel from liposome and cholesterol end capped polyethylene glycol was sys tematically investigated by rheological method especially in the aspect of its recovery ability upon either mechanical deformation or temperature change The liposome gel was found to have theological behavior similar to that of Maxwell model The dynamic shear modulus of the liposome gel was dependent on both the liposome concentration and the polymer concentration At low twosome concentration range (5-20 mM) dynamic shear modulus decreased considerably with the liposome concentration implying the decrease of effective cross linking density inside gel network due to the addition of liposome The liposome gel network had a fast self healing ability even after high deformation and the injectability of the gel was confirmed by injection experiment in vitro The liposome gel also exhibited temperature stimuli responsive behavior and therm reversibility Dynamic light scattering studies proved that the particle size of liposome remained almost unchanged before and after the addition of the polymer (C) 2010 Elsevier B V All rights reserved