Reduction of postoperative adhesion development
Reduction of postoperative adhesion development
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DOI：
10.1016/j.fertnstert.2016.08.029
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发表时间：
2016-10-01
影响因子：
6.7
通讯作者：
Diamond, Michael P.
中科院分区：
文献类型：
--
作者：
Diamond, Michael P.
尽管使用了细致的手术技术，无论是剖腹手术还是腹腔镜手术，绝大多数接受腹盆手术的女性都会发生术后粘连。这种粘连不仅代表粘连松解术部位的粘连重建，也代表外科手术部位的新生粘连形成。抗粘连佐剂的应用补充了精细手术技术的益处，提供了进一步减少术后粘连形成的机会。进一步了解粘连形成的病理生理学，区分无粘连腹膜修复的分子生物学机制的变化，代表了未来改善术后粘连减少的机会。减少术后粘连的优化可能需要识别每个个体的独特的个性化方法，代表腹膜修复过程中的个体差异。(C)2016年，美国生殖医学会（American Society for Reproductive Medicine）
Despite use of meticulous surgical techniques, and regardless of surgical access via laparotomy or laparoscopy, postoperative adhesions develop in the vast majority of women undergoing abdominopelvic surgery. Such adhesions represent not only adhesion reformation at sites of adhesiolysis, but also de novo adhesion formation at sites of surgical procedures. Application of antiadhesion adjuvants compliment the benefits of meticulous surgical techniques, providing an opportunity to further reduce postoperative adhesion development. Improved understanding of the pathophysiology of adhesion development and distinguishing variations in the molecular biologic mechanisms from adhesion-free peritoneal repair represent future opportunities to improve the reduction of postoperative adhesions. Optimization of the reduction of postoperative adhesions will likely require identification of unique, personalized approaches in each individual, representing interindividual variation in peritoneal repair processes. (C) 2016 by American Society for Reproductive Medicine.