Iron-catalysed fluoroaromatic coupling reactions under catalytic modulation with 1,2-bis(diphenylphosphino)benzene
Iron-catalysed fluoroaromatic coupling reactions under catalytic modulation with 1,2-bis(diphenylphosphino)benzene
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DOI：
10.1039/b820879d
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发表时间：
2009-01-01
影响因子：
4.9
通讯作者：
Nakamura, Masaharu
中科院分区：
文献类型：
--
作者：
Hatakeyama, Takuji;Kondo, Yoshiyuki;Nakamura, Masaharu
催化量的1，2-双（二苯基膦基）苯（DPPBz）在铁催化的多氟化芳基锌试剂和烷基卤化物之间的交叉偶联中实现sp（3）-碳-卤素键的选择性裂解，这是用化学计量改性剂如TMEDA无法实现的;选择性铁催化的氟代芳族偶联提供了容易且实用的多氟化芳族化合物的途径。
A catalytic amount of 1,2-bis(diphenylphosphino) benzene (DPPBz) achieves selective cleavage of sp(3)-carbon-halogen bond in the iron-catalysed cross-coupling between polyfluorinated arylzinc reagents and alkyl halides, which was unachievable with a stoichiometric modifier such as TMEDA; the selective iron-catalysed fluoroaromatic coupling provides easy and practical access to poly-fluorinated aromatic compounds.