SUBSTANTIA NIGRA - SITE OF ANTICONVULSANT ACTIVITY MEDIATED BY GAMMA-AMINOBUTYRIC ACID
SUBSTANTIA NIGRA - SITE OF ANTICONVULSANT ACTIVITY MEDIATED BY GAMMA-AMINOBUTYRIC ACID
复制标题
DOI：
10.1126/science.7146907
复制
发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
GALE, K
中科院分区：
文献类型：
--
作者：
IADAROLA, MJ;GALE, K
脑内注射γ-氨基丁酸激动剂，研究GABA介导的抗惊厥作用的解剖底物的定位。通过提高中脑被盖腹侧GABA水平，阻断最大电击试验中强直后肢伸展，阻断戊四氮和荷包牡丹碱所致的强直和阵挛发作。前脑和后脑区GABA的升高对惊厥活动无影响。向中脑微量注射直接的GABA受体激动剂--蝇草酚，也可以阻断强直和阵挛发作。黑质被认为是GABA介导的抗惊厥活性的关键中脑部位。将GABA激动剂局部注射到中脑可以提供癫痫保护，而不会在整个大脑中广泛增强GABA介导的活动，也不会损害警觉性或运动功能。黑质中的突触似乎是抑制全身性惊厥传播的重要控制机制。
Localization of the anatomic substrate for anticonvulsant activity mediated by γ-aminobutyric acid (GABA) was examined using intracerebral injections of GABA agonists. Blockade of tonic hindlimb extension in the maximal electroshock test and blockade of tonic and clonic seizures produced by pentylenetetrazole and bicuculline were obtained by elevating GABA in the ventral midbrain tegmentum. Elevation of GABA in forebrain and hindbrain areas had no effect on convulsant activity. Blockade of tonic and clonic seizures was also obtained after microinjections of the direct GABA receptor agonist, muscimol, into the midbrain. The substantia nigra was identified as the critical midbrain site for GABA-mediated anticonvulsant activity. Local injection of GABA agonists into the midbrain provided seizure protection without a widespread augmentation of GABA-mediated activity throughout the brain and without impairing either alertness or motor function. Synapses in the substantia nigra appear to represent an important control mechanism for inhibiting the propagation of generalized convulsions.