Two-dimensional classification of amphiphilic monomers based on interfacial and partitioning properties. 2. Amino acids and amino acid residues
Two-dimensional classification of amphiphilic monomers based on interfacial and partitioning properties. 2. Amino acids and amino acid residues
复制标题
基于界面和分配特性的两亲单体的二维分类。
DOI：
10.1007/s00396-005-1447-6
复制
发表时间：
2006
影响因子：
2.4
通讯作者：
A. Khokhlov
中科院分区：
文献类型：
--
作者：
I. Okhapkin;A. A. Askadskii;V. Markov;E. Makhaeva;A. Khokhlov
基于界面和配分性质，提出了一种新的氨基酸残基分类方法。氨基酸残基由两个参数表征：正己烷/水界面的标准吸附自由能和正己烷与水之间的标准配分自由能。理论方法用于估计这些参数。结果，几组具有相近值的氨基酸单元被区分出来。通过这种方法对氨基酸单位进行分类被认为能够在寻找蛋白质序列的相关性方面提供有希望的结果。正己烷/水界面上的游离氨基酸的实验和理论研究的比较证实了所使用的理论的预测能力，因为在理论和实验数据点之间观察到非常好的一致性。所得的标准吸附自由能值与文献数据一致。
A new classification for amino acid residues is proposed, based on interfacial and partitioning properties. Amino acid residues are characterized by two parameters: standard free energy of adsorption at the hexane/water interface and standard free energy of the partition between hexane and water. Theoretical approaches are used for the estimation of these parameters. As a result, several groups of amino acid units having close values of the parameters are distinguished. Classification of the amino acid units by such a method is believed to be able to provide promising results in the search of correlations in protein sequences. The comparison of experimental and theoretical studies of free amino acids at the hexane/water interface confirm the predictive power of the theory used, because a very good coincidence between theoretical and experimental data points is observed. The obtained values of standard free energies of adsorption are consistent with literature data.
影响因子：
2.9
作者：
WOLFENDEN, R;ANDERSSON, L;SOUTHGATE, CCB
通讯作者：
SOUTHGATE, CCB