Hyperactivity in the medial olivocochlear efferent system is a common feature of tinnitus and hyperacusis in humans.
Hyperactivity in the medial olivocochlear efferent system is a common feature of tinnitus and hyperacusis in humans.
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DOI：
10.1152/jn.00948.2014
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发表时间：
2015-02
影响因子：
2.5
通讯作者：
Joshua J. Sturm;C. Weisz
中科院分区：
文献类型：
--
作者：
Joshua J. Sturm;C. Weisz
耳鸣和听觉过敏是常见的，沉重的发病率与高并发症的来源。Knudson等人（J Neurophysiol 112：3197-3208，2014）证明，内侧橄榄耳蜗系统对耳蜗活动的传出抑制在患有耳鸣和/或听觉过敏的个体中增强。他们的研究结果强调，传出听觉通路的非典型活动可能代表耳鸣和听觉过敏的共同底物，以及潜在的治疗靶点。
Tinnitus and hyperacusis are common, burdensome sources of morbidity with a high rate of co-occurrence. Knudson et al. (J Neurophysiol 112: 3197-3208, 2014) demonstrated that efferent suppression of cochlear activity by the medial olivocochlear system is enhanced in individuals with tinnitus and/or hyperacusis. Their findings stress that atypical activity in the efferent auditory pathway may represent a shared substrate, as well as a potential therapeutic target, in tinnitus and hyperacusis.