A novel compound, ferulic acid-bound resveratrol, induces the tumor suppressor gene p15 and inhibits the three-dimensional proliferation of colorectal cancer cells
A novel compound, ferulic acid-bound resveratrol, induces the tumor suppressor gene p15 and inhibits the three-dimensional proliferation of colorectal cancer cells
复制标题
一种新型化合物阿魏酸结合白藜芦醇可诱导抑癌基因p15并抑制结直肠癌细胞的三维增殖
DOI：
10.1007/s11010-019-03606-8
复制
发表时间：
2019
影响因子：
4.3
通讯作者：
Kotake Yojiro
中科院分区：
文献类型：
--
作者：
Sawata Yuuga;Matsukawa Taiji;Doi Satoshi;Tsunoda Toshiyuki;Arikawa Nagisa;Matsunaga Natsumi;Ohnuki Koichiro;Shirasawa Senji;Kotake Yojiro
白藜芦醇是一种存在于葡萄和其他可食用食物中的植物抗毒素，据报道对包括癌症在内的各种疾病具有有益作用。我们以前报道，白藜芦醇及其衍生物，咖啡酸加合物白藜芦醇，选择性地抑制三维（3D）增殖的人结直肠癌细胞系，HCT 116与激活KRAS突变。在此，我们证明了一种新的化合物，阿魏酸结合的白藜芦醇，也抑制了HCT 116细胞的3D增殖。我们观察到，与两个阿魏酸缀合的白藜芦醇比白藜芦醇和与一个阿魏酸缀合的白藜芦醇更强烈地抑制HCT 116细胞的3D增殖。与两种阿魏酸结合的白藜芦醇也抑制MCF7人乳腺癌细胞的3D增殖。我们进一步发现，白藜芦醇衍生物增加了肿瘤抑制因子p15的mRNA水平，这是一种CDK抑制剂，在HCT 116细胞中起到细胞增殖的制动作用。这些结果表明白藜芦醇衍生物通过增加HCT 116细胞中p15的表达来抑制3D增殖。
Resveratrol, a phytoalexin present in grapes and other edible foods, has been reported to have beneficial effects against various diseases including cancer. We previously reported that resveratrol and its derivative, caffeic acid-adducted resveratrol, selectively inhibit the three-dimensional (3D) proliferation of a human colorectal cancer cell line, HCT116 with activating KRAS mutation. Herein, we demonstrated that a novel compound, ferulic acid-bound resveratrol, also represses the 3D proliferation of HCT116 cells. We observed that resveratrol conjugated to two ferulic acids represses the 3D proliferation of HCT116 cells more strongly than resveratrol and resveratrol conjugated to one ferulic acid. Resveratrol conjugated to two ferulic acids also inhibited the 3D proliferation of MCF7 human breast cancer cells. We further uncovered that the resveratrol derivative increases the mRNA level of the tumor suppressorp15, a CDK inhibitor that functions as a brake of cell proliferation in HCT116 cells. These results imply that the resveratrol derivative represses 3D proliferation via increasingp15expression in HCT116 cells.
登录
查看更多内容
在结肠隐窝模型中激活的 KRAS 对 DNA 修复相关基因的 3D 特异性抑制。
影响因子：
4.8
作者：
Minom Takata;Junva Tomida;Tomoko Shigechi;Hiroyuki Kitao;Akiko Itava;Masamichi Ishiai;Tsunoda T.
通讯作者：
Tsunoda T.
影响因子：
4.8
作者：
Rich, JN;Zhang, M;Wang, XF
通讯作者：
Wang, XF
影响因子：
56.9
作者：
SHIRASAWA, S;FURUSE, M;SASAZUKI, T
通讯作者：
SASAZUKI, T
影响因子：
10.5
作者：
Kotake, Yojiro;Cao, Ru;Xiong, Yue
通讯作者：
Xiong, Yue