Cross talk between NK cells and adaptive immune cells Killers and beyond: NK-cell-mediated control of immune responses
Cross talk between NK cells and adaptive immune cells Killers and beyond: NK-cell-mediated control of immune responses
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DOI：
10.1002/eji.200838882
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发表时间：
2008-11-01
影响因子：
5.4
通讯作者：
Degli-Esposti, Mariapia A.
中科院分区：
文献类型：
--
作者：
Andoniou, Christopher E.;Coudert, Jerome D.;Degli-Esposti, Mariapia A.
有效的免疫需要先天性和适应性免疫应答的协调激活。NK细胞是先天免疫的主要介质，能够快速响应攻击，通常无需事先激活。NK细胞最公认的功能是其细胞毒性潜力和释放大量细胞因子，特别是IFN-γ的能力。最近，人们已经清楚地认识到NK细胞不仅仅是杀手。事实上，NK细胞在形成适应性免疫中起着关键作用。
Effective immunity requires coordinated activation of innate and adaptive immune responses. NK cells are principal mediators of innate immunity, able to respond to challenge quickly and generally without prior activation. The most acknowledged functions of NK cells are their cytotoxic potential and their ability to release large amounts of cytokines, especially IFN-gamma. Recently, it has become clear that NK cells are more than assassins. Indeed, NK cells play critical roles in shaping adaptive immunity.