Prenatal protein restriction leads to a disparity between aortic and peripheral blood pressure in Wistar male offspring.
Prenatal protein restriction leads to a disparity between aortic and peripheral blood pressure in Wistar male offspring.
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产前蛋白质限制导致 Wistar 雄性后代的主动脉血压和外周血压之间存在差异。
DOI：
10.1113/jphysiol.2010.194928
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Swali A
中科院分区：
文献类型：
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作者：
Swali A
许多动物研究已被用于模拟子宫内暴露于低蛋白饮食对成人血压的影响。通过间接尾袖体积描记法收集的收缩压数据一致显示，与对照组相比，低蛋白暴露啮齿动物后代的压力增加，但该技术受到批评，因为相关的应力伪影可能混淆观察到的效应。相反，无线电遥测系统允许在昼夜循环的清醒和睡眠阶段不受限制地连续监测血压。在这项新的研究中，我们直接比较了使用尾套和无线电遥测系统同时测量的低蛋白和对照喂养母鼠的雄性后代的血压参数。对照大鼠显示尾袖和无线电遥测获得的血压数据之间具有良好的相关性。相反，当通过尾套测量时，低蛋白雄性在8周龄时相对高血压，但当通过遥测测量时，在12周龄时血压显著低于对照组。心率和收缩期长度在两组之间没有差异。模拟尾袖体积描记法（新环境、热、束缚、充气）施加的个体应激方案在对照和低蛋白动物中引起了相似的血压和心率增加，排除了产前蛋白质限制后对应激的升压反应增强的影响。相反，认为这些动物的外周血管阻力可能增加。中心和外周血压测量之间的这种差异可能对心血管风险评估和治疗具有重要的临床意义。
A host of animal studies have been used to model the effects of exposure to a low protein dietin uteroon adult blood pressure. Collection of systolic blood pressure data by the indirect tail‐cuff plethysmography method consistently shows increased pressures in low protein exposed rodent offspring compared to controls, but this technique has been criticised as the associated stress artefacts may confound the observed effects. Conversely, radiotelemetry systems allow unrestrained and continuous monitoring of blood pressure through the awake and sleep phases of the diurnal cycle. In this novel study, we directly compared blood pressure parameters in male offspring from low protein and control‐fed dams measured simultaneously using tail‐cuff and radiotelemetry systems. Control rats showed a good correlation between tail‐cuff and radiotelemetry derived blood pressure data. Conversely, low protein males were relatively hypertensive at 8 weeks of age when measured by tail‐cuff, but had significantly lower blood pressure than controls at 12 weeks of age when measured by telemetry. Heart rate and length of systole did not differ between the two groups. Individual stress protocols mimicking those imposed by tail‐cuff plethysmography (novel environment, heat, restraint, inflation), caused similar increases in blood pressure and heart rate in control and low protein animals, ruling out an effect of enhanced pressor response to stress following prenatal protein restriction. Instead, an increase in peripheral vascular resistance in these animals is considered possible. Such a disparity between central and peripheral blood pressure measurements could have important clinical implications regarding cardiovascular risk assessment and treatment.