Solvent‐Cast 3D Printing of Biodegradable Polymer Scaffolds
Solvent‐Cast 3D Printing of Biodegradable Polymer Scaffolds
复制标题
可生物降解聚合物支架的溶剂铸造 3D 打印
DOI：
10.1002/mame.202100442
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发表时间：
2021
影响因子：
3.9
通讯作者：
Chow, Lesley W.
中科院分区：
文献类型：
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作者：
Tolbert, John W.;Hammerstone, Diana E.;Yuchimiuk, Nathaniel;Seppala, Jonathan E.;Chow, Lesley W.
3D打印是一种流行的制造技术，因为它能够制作复杂的建筑。熔融3D打印因其加工温度低而被广泛应用于聚己内酯(PCL)、聚乳酸(PLA)和聚乳酸-乙醇酸(PLGA)等热塑性聚合物。然而，传统的基于熔体的技术需要足够高的加工温度和压力来实现连续流动，这限制了可以打印的聚合物的类型。溶剂浇注印刷(SCP)为印刷更广泛的聚合物提供了另一种方法。聚合物溶解在挥发性溶剂中，在沉积过程中蒸发，生成固体聚合物长丝。因此，SCP需要优化油墨中的聚合物浓度、打印压力和打印速度，以实现所需的打印保真度。在这里，毛细管流动分析显示了印刷压力如何影响过程-PCL、PLA和PLGA油墨的表观粘度。还可以使用流变学来测量油墨粘度，流变学用于将特定的油墨粘度与所有三种聚合物的印刷压力和印刷速度的预测集联系起来。这些结果表明，这种方法可以通过显著减少参数组合的数量来加快优化速度。这一策略可以应用于其他聚合物，以扩大可用SCP打印的聚合物库。
3D printing is a popular fabrication technique because of its ability to produce complex architectures. Melt‐based 3D printing is widely used for thermoplastic polymers like poly(caprolactone) (PCL), poly(lactic acid) (PLA), and poly(lactic‐co‐glycolic acid) (PLGA) because of their low processing temperatures. However, traditional melt‐based techniques require processing temperatures and pressures high enough to achieve continuous flow, limiting the type of polymer that can be printed. Solvent‐cast printing (SCP) offers an alternative approach to print a wider range of polymers. Polymers are dissolved in a volatile solvent that evaporates during deposition to produce a solid polymer filament. SCP, therefore, requires optimizing polymer concentration in the ink, print pressure, and print speed to achieve desired print fidelity. Here, capillary flow analysis shows how print pressure affects the process‐apparent viscosity of PCL, PLA, and PLGA inks. Ink viscosity is also measured using rheology, which is used to link a specific ink viscosity to a predicted set of print pressure and print speed for all three polymers. These results demonstrate how this approach can be used to accelerate optimization by significantly reducing the number of parameter combinations. This strategy can be applied to other polymers to expand the library of polymers printable with SCP.