Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora
Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora
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DOI：
10.1128/aem.01891-06
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发表时间：
2007-02-01
影响因子：
4.4
通讯作者：
Fenical, William
中科院分区：
文献类型：
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作者：
Jensen, Paul R.;Williams, Philip G.;Fenical, William
在这里，我们报告的次级代谢产物的生产和遗传学不同，但密切相关的海洋放线菌属Salinispora物种之间的关联。这种模式出现在一项包括全球收集地点的研究中，它表明次级代谢产物的产生可能是一种与广泛分布的细菌种群相关的物种特异性表型特征。放线菌放线菌型和化学型之间的关联揭示了一种有效的，基于多样性的天然产物发现方法，这与次级代谢产物的产生是菌株特异性的传统观点相矛盾。所观察到的代谢产物的结构多样性，再加上基因探测和系统发育分析，暗示横向基因转移作为负责化合物生产的生物合成基因的来源。这些结果符合选择驱动的途径固定发生在基因收购后的模型，并提供了一个罕见的例子，其中可证明的生理性状已与环境细菌群落的细尺度系统发育结构。
Here we report associations between secondary metabolite production and phylogenetically distinct but closely related marine actinomycete species belonging to the genus Salinispora. The pattern emerged in a study that included global collection sites, and it indicates that secondary metabolite production can be a species-specific, phenotypic trait associated with broadly distributed bacterial populations. Associations between actinomycete phylotype and chemotype revealed an effective, diversity-based approach to natural product discovery that contradicts the conventional wisdom that secondary metabolite production is strain specific. The structural diversity of the metabolites observed, coupled with gene probing and phylogenetic analyses, implicates lateral gene transfer as a source of the biosynthetic genes responsible for compound production. These results conform to a model of selection-driven pathway fixation occurring subsequent to gene acquisition and provide a rare example in which demonstrable physiological traits have been correlated to the fine-scale phylogenetic architecture of an environmental bacterial community.