Extracellular Vesicles as an Advanced Delivery Biomaterial for Precision Cancer Immunotherapy.
Extracellular Vesicles as an Advanced Delivery Biomaterial for Precision Cancer Immunotherapy.
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DOI：
10.1002/adhm.202100650
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发表时间：
2022-03
影响因子：
10
通讯作者：
He M
中科院分区：
文献类型：
--
作者：
Ruan S;Greenberg Z;Pan X;Zhuang P;Erwin N;He M
近年来，许多临床前和临床研究都观察到癌症免疫疗法显示出益处。然而，由于结果不可预测且反应率低，需要新的靶向递送方法和调节剂才能对更广泛的患者群体和癌症类型有效。与合成生物材料相比，细胞外囊泡（EV）通过提供靶向和位点特异性免疫调节，为提高癌症免疫治疗的疗效开辟了一条新途径。在这篇综述中，讨论了对 EV 货物和表面受体的分子理解，它们支撑着细胞靶向特异性和精确调节免疫原性。我们通过肿瘤组织模型回顾了 EV 的表面标志物、囊泡内内容物、内在免疫调节功能和体内药效学行为方面的独特特性，强调了改进精准癌症免疫治疗的关键迹象。还讨论了用于重新编程和指导癌症免疫治疗的新型分子工程策略及其独特的挑战，以阐明 EV 作为癌症免疫治疗生物材料的未来潜力。癌症免疫疗法是治疗癌症的游戏规则改变者。然而，只有一小部分患者能够产生良好的反应，这凸显了新型免疫调节剂的迫切需要。细胞外囊泡作为天然生物材料，通过提供靶向和位点特异性免疫调节，为提高癌症免疫治疗的疗效开辟了一条新途径。
In recent years, cancer immunotherapy has been observed in numerous preclinical and clinical studies for showing benefits. However, due to the unpredictable outcomes and low response rates, novel targeting delivery approaches and modulators are needed for being effective to more broader patient populations and cancer types. Compared to synthetic biomaterials, extracellular vesicles (EVs) specifically open a new avenue for improving the efficacy of cancer immunotherapy by offering targeted and site-specific immunity modulation. In this review, the molecular understanding of EV cargos and surface receptors, which underpin cell targeting specificity and precisely modulating immunogenicity, are discussed. We review unique properties of EVs in terms of their surface markers, intravesicular contents, intrinsic immunity modulatory functions, and pharmacodynamic behavior in vivo with tumor tissue models, highlighting key indications of improved precision cancer immunotherapy. Novel molecular engineered strategies for reprogramming and directing cancer immunotherapeutics, and their unique challenges are also discussed to illuminate EV’s future potential as a cancer immunotherapeutic biomaterial. Cancer immunotherapy is the game changer in treating cancers. However, only a small population of patients could respond well, which highlights the urgent need of novel immunity modulators. Extracellular vesicles as the natural biomaterial open a new avenue for improving the efficacy of cancer immunotherapy by offering targeted and site-specific immunity modulation.
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DOI：
10.1038/mt.2008.1
发表时间：
2008-04
期刊：
Molecular therapy : the journal of the American Society of Gene Therapy
影响因子：
--
作者：
Dai S;Wei D;Wu Z;Zhou X;Wei X;Huang H;Li G
通讯作者：
Li G
影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
影响因子：
12.4
作者：
Bellavia D;Raimondo S;Calabrese G;Forte S;Cristaldi M;Patinella A;Memeo L;Manno M;Raccosta S;Diana P;Cirrincione G;Giavaresi G;Monteleone F;Fontana S;De Leo G;Alessandro R
通讯作者：
Alessandro R
影响因子：
11.2
作者：
Ashiru O;Boutet P;Fernández-Messina L;Agüera-González S;Skepper JN;Valés-Gómez M;Reyburn HT
通讯作者：
Reyburn HT
激活的 T 细胞外泌体通过 Fas 信号通路促进肿瘤侵袭
影响因子：
4.4
作者：
Cai, Zhijian;Yang, Fei;Wang, Jianli
通讯作者：
Wang, Jianli