Emerging roles of the MiT/TFE factors in cancer.
Emerging roles of the MiT/TFE factors in cancer.
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DOI：
10.1016/j.trecan.2023.06.005
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发表时间：
2023-07
期刊：
影响因子：
18.4
通讯作者：
R. Zoncu;R. Perera
中科院分区：
文献类型：
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作者：
R. Zoncu;R. Perera
小眼症/转录因子E（MiT/TFE）转录因子（TF; TFEB、TFE 3、MITF和TFEC）在细胞增殖和质量控制中起核心作用，并且受到影响其定位、稳定性和活性的广泛调控层。最近的研究强调了这些TF在驱动不同的压力适应途径中的更广泛的作用，这些压力适应途径以上下文和组织依赖的方式表现出来。几种人类癌症上调MiT/TFE因子以在营养、能量和药理学挑战的极端波动中生存。新出现的数据表明，减少MiT/TFE因子的活性也可以促进肿瘤发生。在这里，我们概述了最近的研究结果有关的新机制的调节和活动的MiT/TFE蛋白在一些最具侵略性的人类癌症。
The microphthalmia/transcription factor E (MiT/TFE) transcription factors (TFs; TFEB, TFE3, MITF, and TFEC) play a central role in cellular catabolism and quality control and are subject to extensive layers of regulation that influence their localization, stability, and activity. Recent studies have highlighted a broader role for these TFs in driving diverse stress-adaptation pathways, which manifest in a context- and tissue-dependent manner. Several human cancers upregulate the MiT/TFE factors to survive extreme fluctuations in nutrients, energy, and pharmacological challenges. Emerging data suggest that reduced activity of the MiT/TFE factors can also promote tumorigenesis. Here, we outline recent findings relating to novel mechanisms of regulation and activity of MiT/TFE proteins across some of the most aggressive human cancers.