The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor
The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor
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DOI：
10.1038/12978
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发表时间：
1999-09-01
影响因子：
21.3
通讯作者：
Walker, P
中科院分区：
文献类型：
--
作者：
Lembo, PMC;Grazzini, E;Walker, P
黑色素浓缩激素（melanin-concentrating hormone， MCH）的基因敲除研究及其对摄食和能量平衡的影响已经牢固地确立了MCH作为一种促食欲肽激素的地位。在这里，我们确定MCH是孤儿受体SLC-1的配体。大鼠SLC-1被纳米摩尔浓度的MCH激活，并与G蛋白G α (i/o)偶联。SLC-1信使RNA的表达模式与含有MCH的神经末梢的分布一致，并且与已知的MCH中枢效应一致。我们对MCH受体的鉴定可能对开发新的抗肥胖疗法具有重要意义。
Gene-knockout studies of melanin-concentrating hormone (MCH) and its effect on feeding and energy balance have firmly established MCH as an orexigenic (appetite-stimulating) peptide hormone. Here we identify MCH as the ligand for the orphan receptor SLC-1. The rat SLC-1 is activated by nanomolar concentrations of MCH and is coupled to the G protein G alpha(i/o). The pattern of SLC-1 messenger RNA expression coincides with the distribution of MCH-containing nerve terminals and is consistent with the known central effects of MCH, Our identification of an MCH receptor could have implications for the development of new anti-obesity therapies.