Perilipins: a diversity of intracellular lipid droplet proteins.
Perilipins: a diversity of intracellular lipid droplet proteins.
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DOI：
10.1186/s12944-017-0473-y
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发表时间：
2017-04-28
影响因子：
4.5
通讯作者：
Sasabe N
中科院分区：
文献类型：
--
作者：
Itabe H;Yamaguchi T;Nimura S;Sasabe N
细胞内脂滴（LDs）存在于多种细胞类型中，被认为是具有独特球形结构的细胞器。虽然LD不是稳定的脂质储存库，但它们是中性脂质代谢的活性位点，并且包含被含有专门蛋白质的磷脂单层包围的中性脂质或胆固醇核心。然而，大小和蛋白质组成在细胞和组织类型之间变化。周脂蛋白家族的蛋白质已经与LD的表面相关联，并且都携带保守的11-mer重复基序。越来越多的证据表明，所有围脂蛋白参与LD的形成，并在不同的条件下发挥作用的LD功能。在这篇简短的综述中，我们总结了目前的知识，在各种哺乳动物细胞类型的周脂蛋白和脂质代谢酶的作用。
Intracellular lipid droplets (LDs) are found in a wide variety of cell types and have been recognized as organelles with unique spherical structures. Although LDs are not stable lipid-depots, they are active sites of neutral lipid metabolism, and comprise neutral lipid or cholesterol cores surrounded by phospholipid monolayers containing specialized proteins. However, sizes and protein compositions vary between cell and tissue types. Proteins of the perilipin family have been associated with surfaces of LDs and all carry a conserved 11-mer repeat motif. Accumulating evidence indicates that all perilipins are involved in LD formation and that all play roles in LD function under differing conditions. In this brief review, we summarize current knowledge of the roles of perilipins and lipid metabolizing enzymes in a variety of mammalian cell types.