A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
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DOI：
10.1038/30989
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发表时间：
1998-06-04
期刊：
影响因子：
64.8
通讯作者：
Matzinger, P
中科院分区：
文献类型：
--
作者：
Ridge, JP;Di Rosa, F;Matzinger, P
为了产生免疫反应，抗原特异的T辅助细胞和T杀伤细胞必须找到对方，因为它们不能检测到对方的存在，所以它们由装载抗原的树突状细胞结合在一起，显示两者的抗原(1-3)。然而，这种三种细胞的相互作用似乎几乎是不可能的，因为所有三种细胞类型都是罕见的和可迁移的。在这里，我们为这一难题提供了一个潜在的解决方案，我们发现，这三个细胞不需要同时相遇，但辅助细胞可以首先接触树突状细胞并对其进行条件处理，然后树突状细胞被授权刺激杀伤细胞。第一步(帮助)可以通过调节表面分子CD40或通过病毒感染树突状细胞来绕过。这些结果可能解释了长期以来的矛盾观察，即对某些病毒的反应是不依赖于助手的，并引发了树突状细胞可能对不同的条件性信号做出不同的反应的可能性。
To generate an immune response, antigen-specific T-helper and T-killer cells must find each other and, because they cannot detect each other's presence, they are brought together by an antigen-loaded dendritic cell that displays antigens to both(1-3). This three-cell interaction, however, seems nearly impossible because all three cell types are rare and migratory. Here we provide a potential solution to this conundrum, We found that the three cells need not meet simultaneously but that the helper cell can first engage and 'condition' the dendritic cell, which then becomes empowered to stimulate a killer cell. The first step (help) can be bypassed by modulation of the surface molecule CD40, or by viral infection of dendritic cells. These results may explain the longstanding paradoxical observation that responses to some viruses are helper-independent, and they evoke the possibility that dendritic cells may take on different functions in response to different conditioning signals.