COVID-19 related chemosensory changes in individuals with self-reported obesity
COVID-19 related chemosensory changes in individuals with self-reported obesity
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DOI：
10.4193/rhin21.351
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发表时间：
2022-01-01
期刊：
影响因子：
7.2
通讯作者：
Joseph, P. V.
中科院分区：
文献类型：
--
作者：
Bhutani, S.;Coppin, G.;Joseph, P. V.
背景/目标：自我报告的嗅觉丧失是COVID-19感染的一个突出症状，也是远程预筛查这种疾病的一个潜在有用的临床工具。然而，先前存在的化学感觉功能障碍与肥胖可能会减少有用的自我报告的嗅觉损失在这个脆弱的群体。在这里，我们的目标是比较肥胖和非肥胖参与者中COVID-19相关的化学感觉改变，并确定在限制性临床数据收集的背景下，自我报告的嗅觉丧失是否可以预测两组中基于实验室的COVID-19诊断。在对全球横截面数据集的二次分析中，我们比较了患有呼吸系统疾病的参与者自我报告的化学感受能力，（C19+; n = 5156）或阴性（C19-; n = 659）COVID-19实验室检测结果，他们也自我报告患有肥胖症（C19+; n = 433，C19-; n = 86）或没有肥胖症。在肥胖的C19+参与者中，我们观察到非化学感觉症状的相对患病率更高，包括呼吸道和GI症状。至关重要的是，我们发现之前提出的模型也预测了肥胖参与者的C19+诊断。结论：我们得出的结论是，患有肥胖的COVID-19受访者与不肥胖的受访者经历了类似的自我报告的化学感觉丧失。在两组中，自我报告的化学感觉症状对COVID-19感染的预测相似，因此突出了在临床观察受到限制时远程收集症状和合并症的自我报告的潜力。
Background/objectives: Self-reported smell loss is a prominent symptom of COVID-19 infection and a potentially useful clinical tool for remote pre-screening of this disease. However, pre-existing chemosensory dysfunction with obesity may diminish the usefulness of self-reported smell loss in this vulnerable group. Here we aim to compare COVID-19 related chemosensory alterations in participants with and without obesity and determine if self-reported smell loss is predictive of lab-based COVID-19 diagnosis in both groups in the context of restrictive clinical data collection.Subjects/methods: In this secondary analysis of a cross-sectional global dataset, we compared self-reported chemosensory ability in participants with a respiratory illness reporting a positive (C19+; n = 5156) or a negative (C19-; n = 659) COVID-19 laboratory test outcome, who also self-reported to have obesity (C19+; n = 433, C19-; n = 86) or not.Results: Participants with obesity and without obesity reported a similar decline in smell, taste, and chemesthesis during illness. In C19+ participants with obesity, we observed a greater relative prevalence of non-chemosensory symptoms, including respiratory and GI symptoms. Critically, we found that the model previously proposed also predicts C19+ diagnosis in participants with obesity.Conclusions: We conclude that COVID-19 respondents with obesity experience a similar self-reported chemosensory loss as those without obesity. In both groups self-reported chemosensory symptoms are similarly predictive of COVID-19 infection, thus highlighting the potential of collecting self-report of symptoms and comorbidities remotely when clinical observations are restrictive.