mtv shapes the activity gradient of the Dpp morphogen through regulation of thickveins.
mtv shapes the activity gradient of the Dpp morphogen through regulation of thickveins.
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DOI：
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发表时间：
2001
期刊：
影响因子：
4.6
通讯作者：
Y. Funakoshi;M. Minami;T. Tabata
中科院分区：
文献类型：
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作者：
Y. Funakoshi;M. Minami;T. Tabata
果蝇的翅膀由一种形态形成因子Decapentaplegic （Dpp）构成，Dpp是tgfβ超家族的一员，它沿着前室和后室边界表达。Dpp信号的分布和活性部分受其主要I型受体厚静脉（tkv）的表达水平控制。tkv的水平受En和Hh的动态调节。我们已经确定了一个新的基因，粗静脉大师（mtv），它下调tkv的表达，以响应Hh和En。mtv表达由En和Hh控制，与tkv表达互补。在本报告中，我们证明mtv整合了En和Hh的活动，形成了tkv的表达模式。因此，mtv在形成Dpp形态原活性梯度的调控机制中起着关键作用。
Drosophila wings are patterned by a morphogen, Decapentaplegic (Dpp), a member of the TGFbeta superfamily, which is expressed along the anterior and posterior compartment boundary. The distribution and activity of Dpp signaling is controlled in part by the level of expression of its major type I receptor, thickveins (tkv). The level of tkv is dynamically regulated by En and Hh. We have identified a novel gene, master of thickveins (mtv), which downregulates expression of tkv in response to Hh and En. mtv expression is controlled by En and Hh, and is complementary to tkv expression. In this report, we demonstrate that mtv integrates the activities of En and Hh that shape tkv expression pattern. Thus, mtv plays a key part of regulatory mechanism that makes the activity gradient of the Dpp morphogen.