Results of Antiretroviral Treatment Interruption and Intensification in Advanced Multi-Drug Resistant HIV Infection from the OPTIMA Trial
Results of Antiretroviral Treatment Interruption and Intensification in Advanced Multi-Drug Resistant HIV Infection from the OPTIMA Trial
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DOI：
10.1371/journal.pone.0014764
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发表时间：
2011-03-31
期刊：
影响因子：
3.7
通讯作者：
Darbyshire, Janet
中科院分区：
文献类型：
--
作者：
Holodniy, Mark;Brown, Sheldon T.;Darbyshire, Janet
背景：需要对具有多药耐药（MDR）和再治疗选择有限的晚期HIV疾病的最佳医学管理进行指导。我们评估了两种新的抗逆转录病毒（ARV）治疗方法在这种setting.Methods和结果：我们进行了一项262析因随机开放标签对照试验，在患者的CD4细胞计数
Background: Guidance is needed on best medical management for advanced HIV disease with multidrug resistance (MDR) and limited retreatment options. We assessed two novel antiretroviral (ARV) treatment approaches in this setting.Methods and Findings: We conducted a 262 factorial randomized open label controlled trial in patients with a CD4 count