Roles of IL-18 in basophils and mast cells.
Roles of IL-18 in basophils and mast cells.
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DOI：
10.2332/allergolint.55.105
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
T. Yoshimoto;K. Nakanishi
中科院分区：
文献类型：
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作者：
T. Yoshimoto;K. Nakanishi
嗜碱性粒细胞和肥大细胞是过敏原/IgE介导的免疫应答中的效应细胞。它们在气道或其他器官中诱导I型立即免疫应答，导致支气管哮喘和其他过敏性疾病。然而，它们也在宿主防御蠕虫感染中发挥关键作用。当Fc ε RI与过敏原和IgE的复合物连接时，嗜碱性粒细胞和肥大细胞释放大量的Th 2细胞因子和化学介质。因此，这些反应是“获得性变态反应”，并诱导变态反应性疾病，如支气管哮喘。然而，来源于用IL-3培养10天的骨髓细胞的嗜碱性粒细胞和肥大细胞表达IL-18 R α链，并响应于用IL-3和IL-18刺激而产生Th 2细胞因子，而没有Fc ε RI交联。此外，它们在用几种TLR配体如LPS刺激时产生Th 2细胞因子。这一发现可能表明存在过敏原/IgE非依赖性过敏反应，我们将其命名为“先天性过敏反应”。然而，在体内用IL-18和IL-2治疗通过以STAT 6非依赖性方式激活肠粘膜肥大细胞来保护胃肠道线虫感染，这表明针对蠕虫感染的先天性过敏反应的重要性。在这里，我们讨论了IL-18诱导的“先天性过敏反应”在疾病和宿主防御中的功能作用。
Basophils and mast cells are effecter cells in allergen/IgE-mediated immune responses. They induce type 1 immediate immune response in airway or other organ, resulting in bronchial asthma and other allergic diseases. However, they also play a critical role in host defense against infection with helminthes. Upon linkage of FcepsilonRI with a complex of allergen and IgE, basophils and mast cells release a large amount of Th2 cytokines and chemical mediators. Therefore these responses are "acquired allergic responses" and induce allergic diseases, such as bronchial asthma. However, basophils and mast cells derived from cultured bone marrow cells with IL-3 for 10 days express IL-18Ralpha chain and produce Th2 cytokines in response to the stimulation with IL-3 and IL-18 without FcepsilonRI cross-linkage. Furthermore, they produce Th2 cytokines upon stimulation with several TLR ligands, such as LPS. This finding may suggest the presence of allergen/IgE-independent allergic responses, which we would like to designate as "innate allergic response". However, in vivo treatment with IL-18 and IL-2 protects against gastrointestinal nematode infection by activating intestinal mucosal mast cells in STAT6-independent manner, suggesting the importance of innate allergic response against helminth infection. Here we discuss the functional role of IL-18-induced "innate allergic response" in disease and host defense.