The eosinophil and the eye
The eosinophil and the eye
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DOI：
10.1111/j.1398-9995.1997.tb04810.x
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发表时间：
1997-01-01
期刊：
影响因子：
12.4
通讯作者：
Bonini, S
中科院分区：
文献类型：
--
作者：
Bonini, S;Magrini, L;Bonini, S
本文综述了过敏性眼病的个人研究结果，认为：1。春性角膜结膜炎（VKC）患者的结膜活检显示嗜酸性粒细胞数量增加且分布异常。2. 嗜酸性粒细胞和嗜酸性粒细胞产物，如ECP，在VKC患者的泪液中也增加，在花粉热结膜炎中，在特异性过敏原攻击后的过敏反应后期积累。3. VKC患者的循环嗜酸性粒细胞表现出典型的激活表型，这与血清嗜酸性粒细胞阳离子蛋白和嗜酸性粒细胞衍生神经毒素/蛋白x水平升高有关。一项关于西替利嗪对过敏反应早期和晚期以及结膜过敏原攻击后嗜酸性粒细胞激活和组织募集的调节作用的临床研究被报道为需要评估嗜酸性粒细胞功能的一个例子研究抗过敏药物。调节嗜酸性粒细胞各方面功能的药物可能在过敏性眼病的治疗中起主要作用。
Personal studies in allergic eye diseases reviewed in this paper indicate that: 1. An increased number and an abnormal distribution of eosinophils is present in conjunctival biopsies of patients with vernal keratoconjunctivitis (VKC). 2. Eosinophil and eosinophil products, such as ECP, are also increased in tears of VKC patients and, in hay fever conjunctivitis, accumulate during the late-phase of allergic reaction following specific allergen challenge. 3. Circulating eosinophils of VKC patients show a typical activation phenotypic profile which is associated with increased serum level of eosinophil cationic protein and eosinophil-derived neurotoxin/protein X. A clinical study of the modulatory effect of cetirizine on the early and late phase of the allergic reaction as well as on the eosinophil activation and tissue recruitment following conjunctival allergen challenge is reported as an example of the need to evaluate eosinophil functions when investigating anti-allergic drugs. Drugs modulating various aspects of eosinophil function could play a primary role in the treatment of allergic eye disease.