Iontophoresis across the proximal nail fold to target drugs to the nail matrix.
Iontophoresis across the proximal nail fold to target drugs to the nail matrix.
复制标题
穿过近端甲襞的离子电渗疗法将药物靶向至指甲基质。
DOI：
10.1002/jps.23139
复制
发表时间：
2012
影响因子：
3.8
通讯作者：
Murthy,SNarasimha
中科院分区：
文献类型：
--
作者：
Manda,Prashanth;Sammeta,SrinivasaM;Repka,MichaelA;Murthy,SNarasimha
The main objective of the present study was to investigate the plausibility of iontophoretic delivery of drugs to the nail matrix via proximal nail fold. Thein vitrodrug transport studies were performed in Franz diffusion cells across folded epidermis, which is used as a model for the proximal nail fold. The amount of drug transported into the receiver compartment following iontophoresis for 3 h at 0.5 mA/cm2was 150-fold higher than the control (0.008 ± 0.002 μg/cm2). The amount of drug present in the skin after iontophoresis (0.45 ± 0.12 μg/mg) was approximately fivefold higher as compared with that of the control (0.08 ± 0.01 μg/mg). Iontophoresis of terbinafine across the proximal nail fold was assessed using excised cadaver toe model as well. A custom-designed foam-pad-type patch system was used for iontophoresis in cadaver toes. The amount of the drug delivered into the nail matrix following iontophoresis for 3 h was significantly higher than the minimum inhibition concentration of terbinafine. However, on the contrary, passive delivery for about 24 h did not result in any detectable drug levels in the nail matrix. Iontophoresis across the proximal nail fold could be developed as a potential method to target drugs to nail matrix. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association.
