RECOMBINANT HUMAN TUMOR-NECROSIS-FACTOR-ALPHA CONSTRICTS PIAL ARTERIOLES AND INCREASES BLOOD-BRAIN-BARRIER PERMEABILITY IN NEWBORN PIGLETS
RECOMBINANT HUMAN TUMOR-NECROSIS-FACTOR-ALPHA CONSTRICTS PIAL ARTERIOLES AND INCREASES BLOOD-BRAIN-BARRIER PERMEABILITY IN NEWBORN PIGLETS
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DOI：
10.1016/0304-3940(92)90823-p
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发表时间：
1992-12-14
影响因子：
2.5
通讯作者：
SPEER, CP
中科院分区：
文献类型：
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作者：
MEGYERI, P;ABRAHAM, CS;SPEER, CP
肿瘤坏死因子α（TNFα）在中枢神经系统感染的发病机制中发挥着重要作用。我们研究了脑池内注射重组人 TNFα（50-50,000 IU）对新生仔猪软脑膜血管反应性和血脑屏障通透性的影响。细胞因子给药导致动脉血管收缩、血脑屏障对荧光素钠（摩尔重量 376 Da）开放，并以剂量依赖性方式增加所检查的大脑区域（顶叶和枕叶皮质、小脑、脑桥/延髓、脑室周围白质）对荧光素钠的摄取。 TNFα可能参与新生儿脑损伤的病理生理学。
Tumor necrosis factor alpha (TNFalpha) plays a significant role in the pathogenesis of central nervous system infections. We investigated the effect of intracisternal injection of recombinant human TNFalpha (50-50,000 IU) on pial vasoreactivity and blood-brain barrier permeability in newborn piglets. The cytokine administration resulted in arterial vasoconstrictions, blood-brain barrier opening for Na-fluorescein (mol. wt. 376 Da) and increased Na-fluorescein uptake in brain regions examined (parietal and occipital cortex, cerebellum, pons/medulla, periventricular white matter) in a dose-dependent manner. TNFalpha may be involved in the pathophysiology of neonatal brain injuries.