Increased salt retention and hypertension from non-steroidal agents in the elderly.
Increased salt retention and hypertension from non-steroidal agents in the elderly.
复制标题
老年人使用非甾体药物会增加盐潴留和高血压。
DOI：
10.1093/qjmed/90.6.411
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Epstein,FH
中科院分区：
文献类型：
--
作者：
Mulkerrin,EC;Clark,BA;Epstein,FH
我们研究了5名年龄在65 ~ 71岁的血压正常的健康女性对急性盐负荷的血压和利钠反应，以及非甾体类抗炎药对这些反应的影响。5名25 - 31岁的女性作为对照组。静脉内盐水负荷，有或没有预先摄入布洛芬，为15 ml/kg/h，持续3 h。老年人的基线血压较高。盐水输注不含布洛芬仅使老年组的收缩压（SBP）升高约25 mmHg。老年人的基线SBP增加（129 +/- 6 vs. 116 +/- 5 mmHg，p < 0.05）。布洛芬后的盐水负荷再次使老年人的血压升高约25 mmHg。老年组在生理盐水负荷期间钠排泄显著增加，但布洛芬可降低钠排泄。在对照组中，Iceland对SBP或钠排泄没有影响。衰老似乎增加了对非甾体抗炎药引起的盐潴留和高血压的易感性。
We studied blood pressure and natriuretic responses to acute salt loading, and the effect of non-steroidal anti-inflammatory agents on these responses, in five healthy normotensive women aged 65 to 71 years. Five women aged 25 to 31 years acted as controls. Intravenous saline loading, with and without prior ingestion of ibuprofen, was 15 ml/kg/h for 3 h. Baseline blood pressures were higher in the elderly. Saline infusion without ibuprofen raised systolic blood pressure (SBP) by about 25 mmHg in the older group only. Ibuprofen increased baseline SBP in the elderly (129 +/- 6 vs. 116 +/- 5 mmHg, p < 0.05). Saline loading after ibuprofen again raised blood pressure by about 25 mmHg in the elderly only. The elderly group showed markedly increased sodium excretion during saline loading, but this was reduced by ibuprofen. Ibuprofen had no effect on SBP or sodium excretion in controls. Ageing appears to increase susceptibility to salt retention and hypertension from non-steroidal anti-inflammatory agents.