Brain stem neurons in modified pathways for motor learning in the primate vestibulo-ocular reflex.
Brain stem neurons in modified pathways for motor learning in the primate vestibulo-ocular reflex.
复制标题
灵长类前庭眼反射运动学习途径中的脑干神经元经过修改。
DOI：
10.1126/science.3142040
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Pavelko,TA
中科院分区：
文献类型：
--
作者：
Lisberger,SG;Pavelko,TA
前庭眼反射（VOR）通过产生与头部转动幅度相等且方向相反的平滑眼球运动来稳定视网膜图像。每当在头部转动期间持续发生图像运动时，VOR经历运动学习;因此，图像稳定性逐渐恢复。现在已经描述了一组位于经修改的通路中的脑干神经元。在VOR中，神经元表达与运动学习相关的放电变化，并接受小脑小叶的单突触抑制。放电的变化具有适当的幅度，并以正确的潜伏期表示，以解释改变的VOR。神经元的反应特性指向它们的脑干前庭输入，以进一步研究运动学习的位点。
The vestibulo-ocular reflex (VOR) stabilizes retinal images by generating smooth eye movements that are equal in amplitude and opposite in direction to head turns. Whenever image motion occurs persistently during head turns, the VOR undergoes motor learning; as a result image stability is gradually restored. A group of brain stem neurons that are in the modified pathways has now been described. The neurons express changes in firing in association with motor learning in the VOR and receive monosynaptic inhibition from the flocculus of the cerebellum. The changes in firing have an appropriate magnitude and are expressed at the correct latency to account for the altered VOR. The response properties of the neurons point to their brain stem vestibular inputs for further investigation of the site of motor learning.