Natural killer T cells: rapid responders controlling immunity and disease
Natural killer T cells: rapid responders controlling immunity and disease
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DOI：
10.1016/j.biocel.2004.11.019
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发表时间：
2005-07-01
影响因子：
4
通讯作者：
August, A
中科院分区：
文献类型：
--
作者：
Mercer, JC;Ragin, MJ;August, A
自然杀伤T（NKT）细胞是T细胞的一个亚群，具有自然杀伤细胞和常规T细胞的特性。它们参与即时免疫反应、肿瘤排斥、免疫监视以及自身免疫疾病的控制。大多数NKT细胞同时表达一种恒定的T细胞抗原受体和NK细胞受体NK1.1，被称为恒定NKT细胞。这种恒定的T细胞受体仅限于与非经典主要组织相容性复合体（MHC）CD1d所呈递的糖脂相互作用。这些NKT细胞在通过其T细胞受体（TCR）受到刺激时，会迅速产生高水平的白细胞介素（IL）-2、干扰素-γ、肿瘤坏死因子-α和IL - 4。大多数还具有类似于NK细胞的细胞毒活性。NKT细胞与许多病理状况有关，并且已被证明在体内调节病毒感染以及控制肿瘤生长。它们在某些自身免疫疾病的进展中可能也起到保护和有害的双重作用，例如糖尿病、狼疮、动脉粥样硬化和过敏原诱发的哮喘。（c）2004爱思唯尔有限公司。保留所有权利。
Natural killer T (NKT) cells are a subset of T cells that share properties of natural killer cells and conventional T cells. They are involved in immediate immune responses, tumor rejection, immune surveillance and control of autoimmune diseases. Most NKT cells express both an invariant T cell antigen receptor and the NK cell receptor NKL1.1 and are referred to as invariant NKT cells. This invariant T cell receptor is restricted to interactions with glycolipids presented by the non-classical MHC, CD1d. These NKT cells rapidly produce high levels of interleukin (IL)-2, IFN-gamma, TNF-alpha, and IL-4 upon stimulation through their TCR. Most also have cytotoxic activity similar to NK cells. NKT cells are involved in a number of pathological conditions, and have been shown to regulate viral infections in vivo, and control tumor growth. They may also play both protective and harmful roles in the progression of certain autoimmune diseases, such as diabetes, lupus, atherosclerosis, and allergen-induced asthma. (c) 2004 Elsevier Ltd. All rights reserved.