THE EFFECT OF LEUKOTRIENE C-4 AND D4 ON CUTANEOUS BLOOD-FLOW IN HUMANS
THE EFFECT OF LEUKOTRIENE C-4 AND D4 ON CUTANEOUS BLOOD-FLOW IN HUMANS
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DOI：
10.1016/0090-6980(82)90124-1
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发表时间：
1982-01-01
影响因子：
2.9
通讯作者：
SONDERGAARD, J
中科院分区：
文献类型：
--
作者：
BISGAARD, H;KRISTENSEN, J;SONDERGAARD, J
用激光多普勒血流仪测量微血管对LT[白三烯]C4和LTD4的反应。皮内注射1微克LTC4和LTD4导致微血管皮肤血流量增加。血流量的增加与等摩尔量的组胺引起的增加相当。阻止三重反应并没有改变反应。注射组胺和LT后的测量值约为未受干扰皮肤的10-15倍，可能代表最大限度扩张的血管床。注射LT后有轻微的痛感。
Using a laser-Doppler-flowmeter, the microvascular response to LT[leukotriene]C4 and LTD4 was measured. Intradermal injection of 1 .mu.g LTC4 and LTD4 caused an increase in the microvascular cutaneous blood flow. The increase in flow was equal to that caused by histamine in equimolar amounts. Blocking the triple-response did not change the response. The values measured after injection of histamine and LT were about 10-15 times the values found in undisturbed skin and represents probably a maximally dilated vascular bed. Injection of the LT caused a slight sensation of pain.