Acoustic vaporization threshold of lipid-coated perfluoropentane droplets
Acoustic vaporization threshold of lipid-coated perfluoropentane droplets
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DOI：
10.1121/1.5027817
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发表时间：
2018-04-01
影响因子：
2.4
通讯作者：
Sarkar, Kausik
中科院分区：
文献类型：
--
作者：
Aliabouzar, Mitra;Kumar, Krishna N.;Sarkar, Kausik
通过声刺激可蒸发的相移液滴提供了原位产生作为造影剂的微泡以及更高的稳定性和实现更小尺寸的可能性的优点。在此，在室温下，在无管装置中，声学测量具有全氟戊烷（PFP）核（直径400-3000 nm）的液滴悬浮液的声学液滴蒸发（ADV）阈值作为激发频率的函数。散射响应的变化，基本的，分，和二次谐波的影响，一个定量的标准是用来确定ADV现象，并讨论结果。使用三种不同的散射分量获得的平均阈值随频率增加-在2.25 MHz时为1.05 +/- 0.28 MPa，在5 MHz时为1.89 +/- 0.57 MPa，在10 MHz时为2.34 +/- 0.014 MPa。从蒸发液滴的散射响应也被发现定性匹配的幅度，以及上述确定的ADV阈值的趋势，从一个独立制备的脂质涂层微泡悬浮液。(C)2018年美国声学学会。
Phase shift droplets vaporizable by acoustic stimulation offer the advantages of producing micro-bubbles as contrast agents in situ as well as higher stability and the possibility of achieving smaller sizes. Here, the acoustic droplet vaporization (ADV) threshold of a suspension of droplets with a perfluoropentane (PFP) core (diameter 400-3000 nm) is acoustically measured as a function of the excitation frequency in a tubeless setup at room temperature. The changes in scattered responses-fundamental, sub-, and second harmonic-are investigated, a quantitative criterion is used to determine the ADV phenomenon, and findings are discussed. The average threshold obtained using three different scattered components increases with frequency-1.05 +/- 0.28 MPa at 2.25 MHz, 1.89 +/- 0.57 MPa at 5 MHz, and 2.34 +/- 0.014 MPa at 10 MHz. The scattered response from vaporized droplets was also found to qualitatively match with that from an independently prepared lipid-coated microbubble suspension in magnitude as well as trends above the determined ADV threshold value. (C) 2018 Acoustical Society of America.