EFFECT OF PRE-GASTRIC FOOD STIMULI ON MEAL SIZE AND INTER-MEAL INTERVAL IN RAT
EFFECT OF PRE-GASTRIC FOOD STIMULI ON MEAL SIZE AND INTER-MEAL INTERVAL IN RAT
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DOI：
10.1016/0031-9384(78)90305-0
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发表时间：
1978-01-01
影响因子：
2.9
通讯作者：
SMITH, GP
中科院分区：
文献类型：
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作者：
KRALY, FS;CARTY, WJ;SMITH, GP
禁食3 h后，胃瘘大鼠进食流质食物，瘘口关闭（正常喂养）或开放（假喂养）。在第1次假喂养试验中，与正常喂养相比，进食量（MS）较大，餐间间隔（IMI）较短。在这些条件下，在假喂养期间，通过瘘管收集摄入的食物和酚红标记的饲料。单独的胃前食物相关刺激（假喂养）足以终止进餐，出现餐后休息行为，并在类似于实验室大鼠在昼夜周期的光相正常喂养的条件下获得可测量的IMI。单独的胃前刺激对于正常的饱腹感是不够的，因为假喂食的MS比正常的更大，而IMI比正常的更短。这种假喂养模式可以作为一个有用的行为测定餐后饱腹感。
After 3 h food deprivation, rats with gastric fistualas ate liquid food with the fistula closed (normal feeding) or open (sham feeding). On the 1st sham feeding test, meal size (MS) was larger and intermeal interval (IMI) was shorter than during normal feeding. The collection of ingested food and phenol red labeled diet through the fistula was complete during sham feeding under these conditions. Pregastric food-contingent stimuli alone (sham feeding) are sufficient for the termination of a meal, appearance of postprandial resting behavior and for a measurable IMI under conditions resembling those of normal feeding for laboratory rats in the light phase of a diurnal cycle. Pregastric stimuli alone are not sufficient for normal satiety because sham-fed MS is larger and IMI is shorter than normal. This sham feeding paradigm may serve as a useful behavioral assay for postprandial satiety.