Epidemiology of Cryptococcus gattii, British Columbia, Canada, 1999-2007
Epidemiology of Cryptococcus gattii, British Columbia, Canada, 1999-2007
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DOI：
10.3201/eid1601.090900
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发表时间：
2010-02-01
影响因子：
11.8
通讯作者：
MacDougall, Laura
中科院分区：
文献类型：
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作者：
Galanis, Eleni;MacDougall, Laura
加拿大不列颠哥伦比亚省是世界上报告的加蒂隐球菌感染者最多的地方。为了评估疾病的影响，我们回顾分析了1999-2007年间报告的病例、住院和死亡的人口统计学和临床特征。共报告218例，年均发病率为5.8/百万人。寻求治疗的大多数人患有呼吸系统疾病(76.6%)或肺隐球菌病(75.4%)。没有艾滋病毒/艾滋病的人因隐球菌病住院的人比艾滋病毒/艾滋病患者更有可能年龄较大，并因肺部隐球菌病住院。死亡的19人(8.7%)更有可能年龄更大，更有可能患有中枢神经系统疾病和VGIIb菌株感染。尽管不列颠哥伦比亚省的发病率很高，但主要菌株(VGIIa)似乎并不比其他菌株引起更大的疾病或死亡。需要进一步的研究来解释宿主和菌株的特征，以解释受影响人口和疾病结果的区域差异。
British Columbia, Canada, has the largest reported population of Cryptococcus gattii-infected persons worldwide. To assess the impact of illness, we retrospectively analyzed demographic and clinical features of reported cases, hospitalizations, and deaths during 1999-2007. A total of 218 cases were reported (average annual incidence 5.8 per million persons). Most persons who sought treatment had respiratory illness (76.6%) or lung cryptococcoma (75.4%). Persons without HIV/AIDS hospitalized with cryptococcosis were more likely than those with HIV/AIDS to be older and admitted for pulmonary cryptococcosis. The 19 (8.7%) persons who died were more likely to be older and to have central nervous system disease and infection from the VGIIb strain. Although incidence in British Columbia is high, the predominant strain (VGIIa) does not seem to cause greater illness or death than do other strains. Further studies are needed to explain host and strain characteristics for regional differences in populations affected and disease outcomes.