Assessment of Small Pulmonary Blood Vessels in COVID-19 Patients Using HRCT
Assessment of Small Pulmonary Blood Vessels in COVID-19 Patients Using HRCT
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DOI：
10.1016/j.acra.2020.07.019
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发表时间：
2020-10-01
影响因子：
4.8
通讯作者：
De Backer, Wilfried
中科院分区：
文献类型：
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作者：
Lins, Muriel;Vandevenne, Jan;De Backer, Wilfried
原理和目的：越来越多的证据支持肺血流动力学改变在COVID-19发病机制中的作用。以前的研究表明，在肺血容量的变化与肺血管修剪的组织病理学标志物的计算机断层扫描（CT）测量，这表明定量CT分析可能最终是有用的评估肺血管功能障碍更broadly.Materials和方法：建立在以前的工作，自动定量CT测量小血管体积和肺血管密度。对103名COVID-19患者和107名健康志愿者的扫描进行了分析，并对他们的结果进行了比较，在肺叶和整体水平上进行了比较。结果：与健康志愿者相比，COVID-19患者显示BV 5（血管中所含的肺血容量）显著减少。
Rationale and Objectives: Mounting evidence supports the role of pulmonary hemodynamic alternations in the pathogenesis of COVID-19. Previous studies have demonstrated that changes in pulmonary blood volumes measured on computed tomography (CT) are associated with histopathological markers of pulmonary vascular pruning, suggesting that quantitative CT analysis may eventually be useful in the assessment pulmonary vascular dysfunction more broadly.Materials and Methods: Building upon previous work, automated quantitative CT measures of small blood vessel volume and pulmonary vascular density were developed. Scans from 103 COVID-19 patients and 107 healthy volunteers were analyzed and their results compared, with comparisons made both on lobar and global levels.Results: Compared to healthy volunteers, COVID-19 patients showed significant reduction in BV5 (pulmonary blood volume contained in blood vessels of