Schizophrenia and genetics: new insights.
Schizophrenia and genetics: new insights.
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DOI：
10.1007/s11920-996-0051-x
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发表时间：
2002-08-01
影响因子：
6.7
通讯作者：
Brzustowicz, Linda
中科院分区：
文献类型：
--
作者：
Bassett, Anne S;Chow, Eva W;Brzustowicz, Linda
有一致的证据表明，精神分裂症的主要病因涉及易感遗传因素。近年来，在精神分裂症的遗传学方面出现了一些新的见解。几个染色体区域显示出含有精神分裂症易感基因的重要证据。精神分裂症的临床相关遗传亚型（22q缺失综合征）已被确定。有新的证据表明，自发突变可能发挥了作用。遗传咨询有新的建议。迄今为止的进展表明，对精神分裂症遗传易感性的神经发育途径的理解将很快从根本上改变这种复杂疾病的分子遗传学进展。
There is consistent evidence that the principal etiology of schizophrenia involves predisposing genetic factors. Recent years have seen several new insights in the genetics of schizophrenia. Several chromosomal regions show significant evidence that they contain schizophrenia susceptibility genes. A clinically relevant genetic subtype of schizophrenia (22q deletion syndrome) has been identified. There is new evidence that spontaneous mutations may play a role. There are new recommendations for genetic counseling. The progress to date suggests that understanding of a neurodevelopmental pathway from genetic susceptibility to schizophrenia will soon be fundamentally altered by molecular genetic advances in this complex disease.