Versatile synthesis of cationic N-heterocyclic carbene-gold(i) complexes containing a second ancillary ligand. Design of heterobimetallic ruthenium-gold anticancer agents.
Versatile synthesis of cationic N-heterocyclic carbene-gold(i) complexes containing a second ancillary ligand. Design of heterobimetallic ruthenium-gold anticancer agents.
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DOI：
10.1039/c5cc09718e
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发表时间：
2016-02-21
期刊：
影响因子：
--
通讯作者：
Contel M
中科院分区：
文献类型：
--
作者：
Fernández-Gallardo J;Elie BT;Sanaú M;Contel M
我们描述了一种多才多艺的快速合成阳离子金(I)配合物的方法，它含有N-杂环卡宾和第二辅助配体(如膦、亚磷酸盐、精氨酸和胺)，用于合成具有潜在催化和医药应用的化合物。该合成策略已应用于新型阳离子双金属Ru(II)-Au(I)配合物的制备，该配合物对肾癌Caki-1和结肠癌HCT 116细胞株有较高的细胞毒作用，且具有协同效应和比单金属配合物更高的选择性。在[金(I)-NHC]+片段中加入第二中性配体以制备单金属和多金属化合物的新合成策略。
We describe a versatile and quick route to cationic gold(I) complexes containing N-heterocyclic carbenes and a second ancillary ligand (such as phosphanes, phosphites, arsines and amines) of interest for the synthesis of compounds with potential catalytic and medicinal applications. The general synthetic strategy has been applied to the preparation of novel cationic heterobimetallic ruthenium(II)-gold(I) complexes that are highly cytotoxic on renal cancer Caki-1 and colon cancer HCT 116 cell lines while showing a synergistic effect and being more selective than their monometallic counterparts. Novel synthetic strategy to incorporate a second neutral ligand in [gold(I)-NHC]+ fragments for the preparation of mono and multimetallic compounds.