Advance in Human Epithelial-Derived Organoids Research
Advance in Human Epithelial-Derived Organoids Research
复制标题
人类上皮源性类器官研究进展
DOI：
10.1021/acs.molpharmaceut.1c00452
复制
发表时间：
2021
影响因子：
4.9
通讯作者：
Liu Zhonghua
中科院分区：
文献类型：
--
作者：
Li Fengjiao;Zhang Peng;Wu Saizhi;Yuan Lianwen;Liu Zhonghua
Organoids have complex three-dimensional structures that exhibit functionalities and feature architectures similar to those ofin vivoorgans and are developed from adult stem cells, embryonic stem cells, and pluripotent stem cells through a self-organization process. Organoids derived from adult epithelial stem cells are the most mature and extensive. In recent years, using organoid culture techniques, researchers have established various adult human tissue-derived epithelial organoids, including intestinal, colon, lung, liver, stomach, breast, and oral mucosal organoids, all of which exhibit strong research and application prospects. Studies have shown that epithelial organoids are mainly applied in drug discovery, personalized drug response testing, disease mechanism research, and regenerative medicine. In this review, we mainly discuss current organoid culture systems and potential applications of this technique with human epithelial tissue.
