Changes in cancer worry associated with participation in ovarian cancer screening
Changes in cancer worry associated with participation in ovarian cancer screening
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DOI：
10.1002/pon.1151
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发表时间：
2007-09-01
期刊：
影响因子：
3.6
通讯作者：
Wilson, Susan
中科院分区：
文献类型：
--
作者：
Andersen, M. Robyn;Drescher, Chades W.;Wilson, Susan
虽然卵巢癌很罕见，不建议大多数女性进行筛查，但它正在被研究作为降低卵巢癌死亡率的一种方法。随着有效筛查策略的出现，了解参与卵巢癌筛查对生活质量（QOL）的影响将非常重要。在这项研究中，我们研究了参与卵巢癌筛查计划对癌症风险和生活质量的影响。进行了一项随机对照临床试验（n = 592）。没有提示BRCA 1/2突变家族史的女性被随机分配单独或联合接受筛查和风险咨询。结果与随机分配到单独常规护理的妇女进行比较。所有研究组的癌症担忧水平均下降，QOL未受影响;组间无统计学显著差异。在接受异常检测结果的筛查参与者中，发现2年随访时对卵巢癌的担忧程度增加。对于那些收到异常结果的人来说，筛查可能会产生长期影响，并增加对癌症风险的担忧。需要进一步的研究来检验当妇女只得到正常的、可能令人放心的结果时，筛查减少担忧的可能性。版权所有（c）2007约翰威利父子有限公司。
While ovarian cancer is rare and screening is not recommended for most women, it is being studied as a way to reduce ovarian cancer mortality. As effective strategies for screening emerge it will be important to understand the quality of life (QOL) effects of participation in ovarian cancer screening. In this study, we examined the effects of participation in an ovarian cancer screening program on worry about cancer risk and QOL. A randomized controlled clinical trial (n = 592) was conducted. Women without a family history suggestive of a BRCA1/2 mutation were randomly assigned to screening and risk counseling, separately and in combination. Results were compared to women randomized to usual care alone. Levels of cancer worry fell for all study groups and QOL was unaffected; no statistically significant differences were found between groups. Increased levels of worry about ovarian cancer at 2-year follow-up were found among participants in screening receiving abnormal test results. For those who receive abnormal results, screening may have long-term effects and increase worry about cancer risk. Further research will be required to examine the possibility that screening reduces worry when women receive only normal, presumably reassuring, results. Copyright (c) 2007 John Wiley & Sons, Ltd.