Neurobiology of the Premonitory Urge in Tourette's Syndrome: Pathophysiology and Treatment Implications.
Neurobiology of the Premonitory Urge in Tourette's Syndrome: Pathophysiology and Treatment Implications.
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DOI：
10.1176/appi.neuropsych.16070141
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Voon V
中科院分区：
文献类型：
--
作者：
Cavanna AE;Black KJ;Hallett M;Voon V
运动和声音抽搐是相对常见的运动表现，被认为是图雷特综合征的核心特征。尽管传统的描述侧重于客观的现象学观察，如抽搐的解剖位置、数量和频率，但患者的第一人称描述始终报告了特征的主观相关性。这些感觉现象通常被描述为一种内心紧张或急于移动的感觉（“先兆冲动”），这种感觉通过抽搐的表达暂时得到缓解。本文综述了图雷特综合征患者先兆冲动的临床和神经生物学方面的现有文献，重点介绍了其病理生理学和可能的治疗意义。
Motor and vocal tics are relatively common motor manifestations identified as the core features of Tourette syndrome. Although traditional descriptions have focused on objective phenomenological observations, such as anatomical location, number and frequency of tics, patients’ first-person accounts have consistently reported characteristic subjective correlates. These sensory phenomena are often described as a feeling of mounting inner tension or urge to move (“premonitory urge”), which is transiently relieved by tic expression. This paper reviews the existing literature on the clinical and neurobiological aspects of the premonitory urge in patients with Tourette syndrome, with focus on its pathophysiology and possible treatment implications.