Size at birth and abdominal adiposity in adults: a systematic review and meta-analysis
Size at birth and abdominal adiposity in adults: a systematic review and meta-analysis
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DOI：
10.1111/obr.12109
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发表时间：
2014-02-01
期刊：
影响因子：
8.9
通讯作者：
Victora, C. G.
中科院分区：
文献类型：
--
作者：
Araujo de Franca, G. V.;Restrepo-Mendez, M. C.;Victora, C. G.
我们进行了系统的文献综述出生大小和成人腹部肥胖之间的关联，同时也调查成人体重指数（BMI）的调整的作用。检索MEDLINE、Scopus、Web of Science、LILACS和SciELO数据库中截至2013年2月发表的文章。仅纳入前瞻性研究。在筛选了2，570个标题后，我们选择了31篇出版物进行叙述性综合，其中13篇被认为具有较高的方法学质量。确定了六个主要的出生大小指标，出生体重（BW）是最广泛的研究。大多数研究依赖于人体测量作为腹部肥胖的替代品或作为身体脂肪分布的指标。很少有研究通过成像方法评估腹部肥胖，通常样本量较小。11篇文章可纳入荟萃分析。研究发现，成年期体重与腰围呈正相关，但在调整成人BMI后，这种相关性消失。与此相反，体重和腰臀比之间没有关联，而在控制成人BMI后，强烈的负相关变得明显。总之，体重似乎与成人体型较大有关，包括腰围和臀围。校正成人BMI后系数的显著变化表明，出生后生长强烈影响相对中心性肥胖，而BW本身不起作用。鉴于产后生长的潜在影响，需要进一步研究以确定导致腹部肥胖的不同生长轨迹，以及对胎儿和产后生长模式相互作用的研究。
We performed a systematic literature review on the associations between birth size and abdominal adiposity in adults, while also investigating the role of the adjustment for adult body mass index (BMI). MEDLINE, Scopus, Web of Science, LILACS and SciELO databases were searched for articles published up to February 2013. Only prospective studies were included. After screening 2,570 titles, we selected 31 publications for the narrative synthesis, of which 13 were considered to be of high methodological quality. Six main indicators of birth size were identified, and birth weight (BW) was the most extensively studied. Most studies relied on anthropometric measurements as proxies for abdominal fatness or as indicators of body fat distribution. Few studies assessed abdominal adiposity through imaging methods, generally with small sample sizes. Eleven articles could be included in the meta-analyses. BW was found to be positively associated with waist circumference in adulthood, but the association disappeared after adjustment for adult BMI. In contrast, there was no association between BW and waist-to-hip ratio, whereas a strong negative association became evident after controlling for adult BMI. In conclusion, BW seems to be associated with larger adult size in general, including both waist and hip circumferences. The marked change in coefficients after adjustment for adult BMI suggests that post-natal growth strongly affects relative central adiposity, whereas BWper se does not play a role. Given the potential impact of post-natal growth, further research is needed to identify different growth trajectories that lead to abdominal adiposity, as well as studies on interactions of foetal and post-natal growth patterns.