The effect of intrathecal gabapentin on pain behavior and hemodynamics on the formalin test in the rat
The effect of intrathecal gabapentin on pain behavior and hemodynamics on the formalin test in the rat
复制标题
DOI：
10.1097/00000539-199908000-00034
复制
发表时间：
1999-08-01
影响因子：
5.7
通讯作者：
Yaksh, TL
中科院分区：
文献类型：
--
作者：
Yoon, MH;Yaksh, TL
在这项研究中，我们研究了鞘内（IT）加巴喷丁，注射福尔马林到大鼠后爪，疼痛行为和血流动力学的影响。福尔马林诱发双相退缩行为和高血压。II加巴喷丁给药前10分钟福尔马林产生剂量依赖性减少的阶段2，但不是阶段1，退缩和心血管反应。相比之下，IT加巴喷丁给药后9分钟福尔马林对退缩的任何阶段都没有影响。在IT加巴喷丁之前10分钟给予II D-丝氨酸（100 μ g）逆转了加巴喷丁的2期效应。IT加巴喷丁不影响热逃逸潜伏期或基线心血管措施，即使在最大剂量（300 μ g）。这些结果表明，加巴喷丁的脊髓作用减少了躯体交感神经反射和躯体感觉反应的组织损伤，而不伴随急性伤害性感受或静息交感神经流出的影响。含义：组织损伤后，疼痛行为和心血管反应增强，代表脊柱加工的易化状态。加巴喷丁经脊柱给药对静息心率和血压无明显影响，但可减弱损伤引起的疼痛行为和心血管反应。
In this study, we examined the effect of intrathecal (IT) gabapentin, administered before and after the injection of formalin into the rat hindpaw, on pain behavior and hemodynamics. Formalin evoked a biphasic flinching behavior and hypertension. II gabapentin administered 10 min before formalin produced a dose-dependent reduction of the Phase 2, but not Phase 1, flinching and cardiovascular response. In contrast, IT gabapentin administered 9 min after formalin had no effect on either phase of flinching. II D-serine (100 mu g) administered 10 min before IT gabapentin reversed the Phase 2 effect of gabapentin. IT gabapentin did not affect the thermal escape latency or the baseline cardiovascular measures even at the largest dose (300 mu g). These results indicate that the spinal effect of gabapentin reduces the somatosympathetic reflex and somatosensory response to tissue injury without an accompanying effect on acute nociception or resting sympathetic outflow. Implications: After tissue injury, there is an enhanced pain behavior and cardiovascular response, representing a facilitated state of spinal processing. Spinally delivered gabapentin had no evident effect on resting heart rate or blood pressure, but it attenuated the enhanced pain behavior and cardiovascular response otherwise produced by injury.