Fc receptors on mouse placenta and yolk sac cells
Fc receptors on mouse placenta and yolk sac cells
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小鼠胎盘和卵黄囊细胞上的 Fc 受体
DOI：
10.1038/255412a0
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发表时间：
1975
期刊：
影响因子：
64.8
通讯作者：
W. Billington
中科院分区：
文献类型：
--
作者：
J. Elson;E. Jenkinson;W. Billington
在某些物种中，妊娠哺乳动物胎-母界面的大分子交换仅限于胎盘，而在其他物种中，如兔、大鼠和小鼠，卵黄囊也参与其中1。无论是哪种途径，已经确定的是，尽管大多数蛋白质在进入胎儿期间被分解，但一小部分特定的免疫球蛋白完整地转移到胎儿循环中。这不仅对被动免疫的传播，而且对针对胎儿抗原的潜在有害母体抗体的获得具有重要意义。
MACROMOLECULAR exchange across the foeto–maternal interface in the pregnant mammal is in some species confined to the placenta, whereas in others such as the rabbit, rat and mouse, the yolk sac is also involved1. Whatever the route, it is well established that whereas most proteins are broken down during their passage into the foetus, a small proportion of certain immunoglobulins is transferred to the foetal circulation intact. This has important implications not only for the transmission of passive immunity but also for the access of potentially deleterious maternal antibody directed against foetal antigens.