Genetic architecture of growth traits revealed by global epistatic interactions.
Genetic architecture of growth traits revealed by global epistatic interactions.
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通过全局上位相互作用揭示的生长性状的遗传结构。
DOI：
10.1093/gbe/evr065
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发表时间：
2011
影响因子：
3.3
通讯作者：
Gu,Zhenglong
中科院分区：
文献类型：
--
作者：
Xu,Lin;Jiang,Huifeng;Chen,Hong;Gu,Zhenglong
长期以来，上位性一直被认为对于理解生物系统的结构、功能和进化动力学至关重要。然而，人们对它在特定特征下的分布方式知之甚少。基于面包酵母、酿酒酵母的上位相互作用的全局图谱，我们发现上位现象很普遍（比随机预期增加约 13%），并显示出相同生长性状背后的基因之间的模块化结构。更有趣的是，我们的结果表明，负责相同生长性状的中心基因往往比随机预期更频繁地相互上位连接。我们的结果为真核生物生长性状的遗传结构提供了全基因组视角。
Epistasis has long been recognized as fundamentally important in understanding the structure, function, and evolutionary dynamics of biological systems. Yet, little is known about how it is distributed underlying specific traits. Based on a global map of epistatic interactions in baker's yeast,Saccharomyces cerevisiae, we show that epistasis is prevalent (∼13% increase from random expectation) and displays modular architecture among genes that underlie the same growth traits. More interestingly, our results indicate that hub genes responsible for the same growth traits tend to link epistatically with each other more frequently than random expectation. Our results provide a genome-wide perspective on the genetic architecture of growth traits in a eukaryotic organism.