Evolutionary dynamics of a mitochondrial rearrangement "hot spot" in the hymenoptera
Evolutionary dynamics of a mitochondrial rearrangement "hot spot" in the hymenoptera
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DOI：
10.1093/oxfordjournals.molbev.a026111
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发表时间：
1999-02-01
影响因子：
10.7
通讯作者：
Austin, AD
中科院分区：
文献类型：
--
作者：
Dowton, M;Austin, AD
在细胞色素氧化酶II和ATP酶8基因的交界处的tRNA Penes的安排进行了检查，在广泛的Hytera。在过去1.8亿年（Apocrita亚目）中分化的一组黄蜂中，发现了七种不同的tRNA基因排列;许多重排代表了进化上独立的事件。大约相等比例的局部重排，倒位和易位观察到，在脊椎动物线粒体，其中局部重排占主导地位。令人惊讶的是，在某些类型的重排中，同源性是明显的;在昆虫纲中，近形基因顺序的逆转出现在三个不同的场合。而tRNA（H）基因已经在两个不同的情况下易位到该位点。系统发育分析表明，该基因易位是真实的，而不是由于tRNA基因复制后反密码子突变而引起的人为易位。围绕该区域的基因间序列的性质并不表明它应该特别容易重排，它通常不具有可能促进这种可塑性的串联或反向重复序列。有趣的是，这些发现与以下观点相一致：在Hyattera的进化过程中，重排增加的同时，点突变率和组成偏差也增加了。这种关联可能会直接在其他无脊椎动物谱系的线粒体基因组可塑性的调查。
The arrangement of tRNA Penes at the junction of the cytochrome oxidase II and ATPase 8 genes was examined across a broad range of Hymenoptera. Seven distinct arrangements of tRNA genes were identified among a group of wasps that have diverged over the last 180 Myr (suborder Apocrita); many of the rearrangements represent evolutionarily independent events. Approximately equal proportions of local rearrangements, inversions, and translocations were observed, in contrast to vertebrate mitochondria, in which local rearrangements predominate. Surprisingly, homoplasy was evident among certain types of rearrangement; a reversal of the plesiomorphic gene order has arisen on three separate occasions in the Insecta. while the tRNA(H) gene has been translocated to this locus on two separate occasions. Phylogenetic analysis indicates that this gene translocation is real and is not an artifactual translocation resulting from the duplication of a resident tRNA gene followed by mutation of the anticodon. The nature of the intergenic sequences surrounding this region does not indicate that it should be especially prone to rearrangement, it does not generally have the tandem or inverted repeats that might facilitate this plasticity. Intriguingly, these findings are consistent with the view that during the evolution of the Hymenoptera, rearrangements increased at the same time that the rate of point mutations and compositional bias also increased. This association may direct investigations into mitochondrial genome plasticity in other invertebrate lineages.