The association of mood disorders with breast cancer survival: an investigation of linked cancer registration and hospital admission data for South East England
The association of mood disorders with breast cancer survival: an investigation of linked cancer registration and hospital admission data for South East England
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DOI：
10.1002/pon.4037
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发表时间：
2016-01-01
期刊：
影响因子：
3.6
通讯作者：
Jack, R. H.
中科院分区：
文献类型：
--
作者：
Kanani, R.;Davies, E. A.;Jack, R. H.
背景数据关联研究发现，乳腺癌诊断之前或之后的抑郁预示着生存率的下降。本研究旨在确定常规住院数据中记录的抑郁或双相情感障碍是否独立预测英国乳腺癌患者的生存，以及与癌症诊断相关的发病是否有意义。方法收集2000年至2009年英格兰东南部77173名被诊断为乳腺癌(ICD-10 C50)的女性患者的数据。在这些患者中，有131名女性在癌症确诊前3年至确诊后一年期间被诊断为双相情感障碍(ICD-10 F31)和955名抑郁症(抑郁发作(ICD-10 F32)或抑郁障碍(ICD-10 F33))。Kaplan-Meier图用于检查总体存活率。结果抑郁病史是乳腺癌患者总体生存不良的预测因素(校正后HR=1.33，95%CI：1.20~1.48，P
BackgroundData linkage studies find that depression before or after a breast cancer diagnosis predicts reduced survival. This study aimed to determine whether depression or bipolar recorded in routine hospital admission data independently predicts survival in English breast cancer patients and whether onset in relation to cancer diagnosis is significant.MethodsData on 77173 women diagnosed with breast cancer (ICD-10 C50) in South East England, 2000-2009, were included. Of these, 131 women had a diagnosis of bipolar affective disorder (ICD-10 F31) and 955 of depression (either depressive episodes (ICD-10 F32) or depressive disorder (ICD-10 F33)) recorded in Hospital Episode Statistics between 3years before and a year following cancer diagnosis. Kaplan-Meier plots were used to examine overall survival. Cox regression analyses were carried out overall and separately for mood disorder diagnoses before and after the cancer diagnosis and adjusted for confounding variables.ResultsA record of depression was a predictor of worse overall survival in breast cancer patients (adjusted HR=1.33, 95% CI: 1.20-1.48, p