fMRI activity in the medial temporal lobe during famous face processing
fMRI activity in the medial temporal lobe during famous face processing
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DOI：
10.1016/j.neuroimage.2005.09.060
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发表时间：
2006-04-01
期刊：
影响因子：
5.7
通讯作者：
Fransson, P
中科院分区：
文献类型：
--
作者：
Elfgren, C;van Westen, D;Fransson, P
当前的事件相关fMRI研究检查了内侧颞叶（MTI）不同部分的相对参与，特别是海马和周围皮层的贡献，无论是有意还是无意地识别著名的面孔，与不熟悉的面孔相比。我们的目的是进一步探讨MTL在语义记忆任务处理中的有争议的贡献。受试者观看一系列著名和不熟悉的面孔。研究人员使用了两项任务来鼓励人们关注名声或性别。在成名任务中，受试者被要求在看到这个人的脸时认出他/她，并试着说出这个人的名字。在性别任务中，受试者被要求在看到一个人的脸时判断他/她的性别。因此，视觉处理是针对性别的，因此预期会减少对语义信息的关注，导致只对著名和不熟悉的面孔进行“被动”登记。在两种对比中，对名人面孔的识别都显著激活了MTL。首先，在有意识别（人识别任务）过程中，观察到靠近杏仁核的左海马前外侧部分活动增加。其次，在偶然识别名人面孔（性别分类任务）时，左后颞叶的活动增加，焦点集中在嗅周皮层。我们的研究结果表明，海马体可能集中参与语义记忆的有意检索，而周围皮层则与语义信息的偶然识别有关。(c) 2005爱思唯尔公司版权所有。
The current event-related fMRI study examined the relative involvement of different parts of the medial temporal lobe (MTI,), particularly the contribution of hippocampus and perirhinal cortex, in either intentional or incidental recognition of famous faces in contrast to unfamiliar faces. Our intention was to further explore the controversial contribution of MTL in the processing of semantic memory tasks. Subjects viewed a sequence of famous and unfamiliar faces. Two tasks were used encouraging attention to either fame or gender. In the fame task, the subjects were requested to identify the person when seeing his/her face and also to try to generate the name of this person. In the gender task, the subjects were asked to conduct a judgement of a person's gender when seeing his/her face. The visual processing was hence directed to gender and thereby expected to diminish attention to semantic information leading only to a "passive" registration of famous and non-familiar faces.Recognition of famous faces, in both contrasts, produced significant activations in the MTL. First, during the intentional recognition (the person identification task) increased activity was observed in the anterolateral part of left hippocampus, in proximity to amygdala. Second, during the incidental recognition of famous faces (the gender classification task), there was increased activity in the left posterior MTL with focus in the perirhinal cortex. Our results suggest that the hippocampus may be centrally involved in the intentional retrieval of semantic memories while the perirhinal cortex is associated with the incidental recognition of semantic information. (c) 2005 Elsevier Inc. All rights reserved.