Mapping the antigenic and genetic evolution of influenza virus
Mapping the antigenic and genetic evolution of influenza virus
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DOI：
10.1126/science.1097211
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发表时间：
2004-07-16
期刊：
影响因子：
56.9
通讯作者：
Fouchier, RAM
中科院分区：
文献类型：
--
作者：
Smith, DJ;Lapedes, AS;Fouchier, RAM
流感A（H3N2）病毒的抗原演化是从1968年至2003年从引入人类引入的。尽管抗原和遗传进化之间存在显着的对应关系，但观察到显着差异：抗原进化的差异更大，有时比遗传变化有时比遗传变化更具刺激性，并且有时比遗传变化具有无效的大型抗生殖效应。该方法易于监测疫苗和循环菌株之间的抗原差异，从而估计疫苗接种的作用。此外，这种方法为预测新兴菌株的相对成功提供了途径，这可以通过量化种群水平免疫逃生和病毒适应性对应变进化的综合作用来实现。
The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003. Although there was remarkable correspondence between antigenic and genetic evolution, significant differences were observed: Antigenic evolution was more punctuated than genetic evolution, and genetic change sometimes had a disproportionately large antigenic effect. The method readily allows monitoring of antigenic differences among vaccine and circulating strains and thus estimation of the effects of vaccination. Further, this approach offers a route to predicting the relative success of emerging strains, which could be achieved by quantifying the combined effects of population level immune escape and viral fitness on strain evolution.