Dietary cholesterol does not increase biomarkers for chronic disease in a pediatric population from northern Mexico
Dietary cholesterol does not increase biomarkers for chronic disease in a pediatric population from northern Mexico
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DOI：
10.1093/ajcn/80.4.855
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发表时间：
2004-10-01
影响因子：
7.1
通讯作者：
Fernandez, ML
中科院分区：
文献类型：
--
作者：
Ballesteros, MN;Cabrera, RM;Fernandez, ML
背景：在墨西哥北方，冠状动脉疾病（CAD）的发病率普遍增加。特定饮食成分对儿童CAD危险因素的影响尚未进行评估。目的：目的是评估全蛋提供的膳食胆固醇对该地区儿童脂蛋白谱、LDL大小和表型的影响。设计：儿童（29名女孩和25名男孩，年龄8-12岁）被随机分配到2个鸡蛋/天（EGG阶段; 518 mg额外胆固醇）或等量的蛋清（ESTA阶段; 0额外mg胆固醇）30天。结果：受试者分为低反应者（增加100 mg胆固醇，血浆胆固醇无增加或增加小于或等于0.05 mmol/L）和高反应者（增加大于或等于0.06 mmol/L）。在EGG期间，高反应者（n = 18）的LDL胆固醇（从1.54 +/- 0.38至1.93 +/- 0.36 mmol/L）和HDL胆固醇（从1.23 +/- 0.26至1.35 +/- 0.29 mmol/L）均升高，LDL：HDL无变化。相比之下，低反应者（n = 36）的血浆LDL或HDL胆固醇没有显著变化。所有受试者在EGG期间LDL峰直径增加（P < 0.01），LDL较小亚组分减少（P < 0.01）。此外，5个具有LDL表型B（15%）的儿童从这种高风险模式转移到模式A后EGGtreatment.Conclusions：摄入2个鸡蛋/d的结果在维护LDL：HDL和在墨西哥儿童的这一人群中产生的致动脉粥样硬化性较低的LDL。
Background: An increased incidence of coronary artery disease (CAD) is prevalent in northern Mexico. Effects of specific dietary components on risk factors for CAD have not been evaluated in children.Objective: The purpose was to evaluate the effects of dietary cholesterol provided by whole eggs on the lipoprotein profile, LDL size, and phenotype in children from this region.Design: Children (29 girls and 25 boys aged 8-12 y) were randomly assigned to either 2 eggs/d (EGG period; 518 additional mg cholesterol) or the equivalent amount of egg whites (SUB period; 0 additional mg cholesterol) for 30 d. After a 3-wk washout period, the children were assigned to the alternate treatment.Results: Subjects were classified as hyporesponders (no increase or less than or equal to0.05 mmol/L increase in plasma cholesterol for 100 mg additional cholesterol) or hyperresponders (greater than or equal to0.06 mmol/L increase). During the EGG period, the hyperresponders (n = 18) had an elevation in both LDL cholesterol (from 1.54 +/- 0.38 to 1.93 +/- 0.36 mmol/L) and HDL cholesterol (from 1.23 +/- 0.26 to 1.35 +/- 0.29 mmol/L) with no changes in LDL:HDL. In contrast, hyporesponders (n = 36) had no significant alterations in plasma LDL or HDL cholesterol. All subjects had an increase in LDL peak diameter during the EGG period (P < 0.01) and a decrease (P < 0.01) in the smaller LDL subfractions. In addition, 5 of the children having LDL phenotype B (15%) shifted from this high-risk pattern to pattern A after the EGG treatment.Conclusions: Intake of 2 eggs/d results in the maintenance of LDL: HDL and in the generation of a less atherogenic LDL in this population of Mexican children.